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- W2042596559 abstract "By combining the structural features of indole and barbituric acid, new hybrid molecules were designed and synthesized. Evaluations of these molecules over 60 cell line panel of human cancer cells have identified two molecules with significant anticancer activities. Dockings of two active molecules in the active sites of COX-2, thymidylate synthase and ribonucleotide reductase indicate their strong interactions with these enzymes." @default.
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- W2042596559 date "2009-06-01" @default.
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- W2042596559 title "Design, synthesis and anticancer activities of hybrids of indole and barbituric acids—Identification of highly promising leads" @default.
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- W2042596559 doi "https://doi.org/10.1016/j.bmcl.2009.04.014" @default.
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