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- W2042597030 abstract "Time-resolved optical imaging technique offers the promise for development of safe, noninvasive, and inexpensive clinical imaging modalities with diagnostic ability. However, the presence of mismatched refractive-index boundaries in a soft tissue will tremendously change light propagation path, which in turn, makes the optical image obscure if not indiscernible. In this article, a time-resolved Monte Carlo model, which takes into account the photon reflection/transmission behavior at the mismatched refractive-index boundaries, is developed to investigate transient light propagation in biological tissues with embedded tumors and blood vessels. The results show that the temporal reflection signal displays two peak values when refractive-index mismatched foreign objects, such as tumors or blood vessels, are embedded in the tissue. One peak is a direct result arising from the pulse nature of the incident laser light, and the other is due to the backscattering from the refractive-index mismatched boundaries. This suggests that the occurrence of the second peak be an indication for the location and size of tumors inside the tissue." @default.
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- W2042597030 date "2006-01-01" @default.
- W2042597030 modified "2023-10-15" @default.
- W2042597030 title "Analysis of Ultrafast Laser Propagation in Biological Tissues With Embedded Tumors and Large Blood Vessels" @default.
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- W2042597030 doi "https://doi.org/10.1115/imece2006-13791" @default.
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