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- W2042604807 abstract "York in genetics, as in most other branches of biology, has so far been essentially analytical. A century of dissection of heredity has led to a reasonable picture of that the ‘factor’ disclosed by Mendel’s work is made of and how it carries specificity. The gap created between the factor and the character is progressively hied by well-defined molecules. It seems justified to hope that, in some not too instant future, the structure and properties of such molecules will be sufficiently understood. The main programme for the Mendel bicentenary will probably consist essentially determining how molecular structures recognize each other to form cellular superstructures and how they interact in vivo to coordinate the extraordinarily complex chemistry of the cell. In genetics, this problem is merely that of the chromosomal structure, of its regulation and its reproduction in strict coordination with cellular growth and division. It seems fair to say that, if some analytical information concerning the components of a chromosome is now available, little known about the molecular arrangement of these components. As for the reproduction of chromosomes, this is obviously a very complicated process since it represents a crucial event in the chemistry of the cell and must therefore be a losely connected with a great many other processes. The complexity of this feroblem is exemplified by the following argument: there exists good experimental evidence indicating that DNA does replicate according to the mechanism that Watson & Crick (1953) predicted from their model; furthermore, from the work of Kornberg (1961) and his colleagues, an enzyme is known which, in vitro , is able order and polymerize deoxynucleotides according to the sequence imposed by DNA template; yet if a fragment of bacterial DNA is transferred to a recipient bacterium, by transformation or incomplete conjugation, it appears to be unable to be replicated as such. It is replicated only when it has been integrated, as a result of genetic recombination with one of the DNA structures present in the bacterial cells." @default.
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- W2042604807 date "1966-03-22" @default.
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- W2042604807 title "On the association between <i>DNA</i> and membrane in bacteria" @default.
- W2042604807 doi "https://doi.org/10.1098/rspb.1966.0029" @default.
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