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- W2042611980 abstract "Simian varicella virus infection of the African green monkey was inhibited by (E)-5-(2-bromovinyl)-2′-deoxyuridine (BVDU). Treatment at 10 mg/kg/day by oral, intramuscular or intravenous administration prevented the development of viremia and the appearance of rash, and averted the anorexia normally observed in untreated virus-infected monkeys. BVDU reduced the clinical disease when administered orally at either 15, 10 or 5 mg/kg/day BID, but even at 1 mg/kg/day it produced a slight inhibitory effect on the disease. BVDU given by gavage at 15 mg/kg/day as late as 6 days after virus inoculation was observed to modify the course of the disease. Antiviral efficacy of BVDU in the treatment of simian varicella virus-infected monkeys exceeded that observed in similar experiments with acyclovir, adenine-5′-monophosphate, phosphonoacetate or phosphonoformate. The similarity of simian varicella virus to human varicella zoster virus points to the potential efficacy of BVDU in the treatment of generalized varicella infection in humans." @default.
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- W2042611980 date "1981-12-01" @default.
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- W2042611980 title "Inhibition of simian varicella virus infection of african green monkeys by (E)-5-(2-bromovinyl)-2′-deoxyuridine (BVDU)" @default.
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- W2042611980 doi "https://doi.org/10.1016/0166-3542(81)90024-3" @default.
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