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• W2042619233 abstract "Summary Lipocalin allergens, which contain most of the important animal‐derived respiratory sensitizers, induce T helper type 2 (Th2) deviation, but the reasons for this are not clear. To explore the prospects for peptide‐based allergen immunotherapy and to elucidate the characteristics of the immunodominant epitope of Bos d 2, BALB/c mice were immunized with a peptide containing the epitope, peptides containing its analogues, peptides from the corresponding regions of other lipocalin proteins, and peptides with a homologous sequence. We observed that murine spleen cells recognized the immunodominant epitope of Bos d 2, p127–142, in almost the same way as human Bos d 2‐specific T cells did. Enzyme‐linked immunosorbent spot‐forming cell assay (ELISPOT) analyses showed that p127–142 and a corresponding peptide from horse Equ c 1 induced a Th2‐deviated cellular response, whereas a homologous bacterial peptide from Spiroplasma citri induced a Th0‐type response. Interestingly, the spleen cell response to the bacterial peptide and p127–142 was cross‐reactive, that is, able to induce reciprocally the proliferation and cytokine production of primed spleen cells in vitro. More importantly, the peptides were able to skew the phenotype of T cells primed with the other peptide. Our results suggest that modified peptides can be useful in allergen immunotherapy." @default.
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• W2042619233 date "2008-01-18" @default.
• W2042619233 modified "2023-10-15" @default.
• W2042619233 title "Immunotherapeutic potential of the immunodominant T-cell epitope of lipocalin allergen Bos d 2 and its analogues" @default.
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• W2042619233 doi "https://doi.org/10.1111/j.1365-2567.2007.02699.x" @default.
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