FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042621050> ?p ?o ?g. }

• W2042621050 endingPage "20" @default.
• W2042621050 startingPage "10" @default.
• W2042621050 abstract "Store-operated Ca2+ entry (SOCE) plays an important role in the contraction and proliferation of pulmonary artery smooth muscle cells (PASMCs). The aim of this study was to characterise the pharmacological properties of the SOCE pathway in freshly isolated PASMCs from rat lung and to determine whether this Ca2+ entry pathway is sensitive to nitric oxide donor drugs. Following depletion of Ca2+ from the sarcoplasmic reticulum, by treating cells with thapsigargin, re-addition of Ca2+ produced an increase in cytosolic fluo-4 fluorescence that was sustained for the period that extracellular Ca2+ was present. Thapsigargin also increased the rate of quench of fura-2 fluorescence, confirming that SOCE was activated. The SOCE pathway was not affected by nifedipine or verapamil; however, it was inhibited by the divalent cations Ni2+ (10 μM) and Cd2+ (10 μM) by 47 ± 5% and 49 ± 5% respectively. SOCE was also inhibited 42 ± 5% by 2-aminoethoxydiphenyl borate (2-APB; 75 μM) and 58 ± 4% by Gd3+ (10 μM), although La3+ (100 μM) had little effect. None of the NO donors examined, including sodium nitroprusside, glyceryl trinitrate, and 2-(N,N-diethylamino)-diazenolate-2-oxide had any effect on SOCE. Thus, the pulmonary vasorelaxation produced by NO does not involve direct inhibition of SOCE in PASMCs. Western blot and immunocytochemistry using antibodies directed against specific TRPC subunits detected the presence of TRPC1, 3, and 6 in pulmonary artery and the pharmacological profile of SOCE in PASMCs favours a role for TRPC1 in mediating the underlying channels that are activated by store depletion." @default.
• W2042621050 created "2016-06-24" @default.
• W2042621050 creator A5026013572 @default.
• W2042621050 creator A5036979193 @default.
• W2042621050 creator A5089740171 @default.
• W2042621050 date "2008-04-01" @default.
• W2042621050 modified "2023-10-15" @default.
• W2042621050 title "Pharmacological profile of store-operated Ca2+ entry in intrapulmonary artery smooth muscle cells" @default.
• W2042621050 cites W145796029 @default.
• W2042621050 cites W1480206754 @default.
• W2042621050 cites W1562217750 @default.
• W2042621050 cites W1589364751 @default.
• W2042621050 cites W1794236190 @default.
• W2042621050 cites W1968746439 @default.
• W2042621050 cites W1972815989 @default.
• W2042621050 cites W1975297292 @default.
• W2042621050 cites W1980313156 @default.
• W2042621050 cites W1980794984 @default.
• W2042621050 cites W1984373665 @default.
• W2042621050 cites W1992479089 @default.
• W2042621050 cites W2001614832 @default.
• W2042621050 cites W2017703675 @default.
• W2042621050 cites W2021340897 @default.
• W2042621050 cites W2022787032 @default.
• W2042621050 cites W2023675579 @default.
• W2042621050 cites W2024221104 @default.
• W2042621050 cites W2047739982 @default.
• W2042621050 cites W2048348799 @default.
• W2042621050 cites W2060510646 @default.
• W2042621050 cites W2064241631 @default.
• W2042621050 cites W2064686740 @default.
• W2042621050 cites W2066884639 @default.
• W2042621050 cites W2067071582 @default.
• W2042621050 cites W2070885879 @default.
• W2042621050 cites W2078824120 @default.
• W2042621050 cites W2090431935 @default.
• W2042621050 cites W2094030162 @default.
• W2042621050 cites W2100577158 @default.
• W2042621050 cites W2116669059 @default.
• W2042621050 cites W2119095639 @default.
• W2042621050 cites W2127279692 @default.
• W2042621050 cites W2128450740 @default.
• W2042621050 cites W2134568641 @default.
• W2042621050 cites W2137258759 @default.
• W2042621050 cites W2148806848 @default.
• W2042621050 cites W2150091977 @default.
• W2042621050 cites W2158981030 @default.
• W2042621050 cites W2163917074 @default.
• W2042621050 cites W2254871804 @default.
• W2042621050 cites W2422829812 @default.
• W2042621050 cites W79459862 @default.
• W2042621050 doi "https://doi.org/10.1016/j.ejphar.2008.01.018" @default.
• W2042621050 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18308301" @default.
• W2042621050 hasPublicationYear "2008" @default.
• W2042621050 type Work @default.
• W2042621050 sameAs 2042621050 @default.
• W2042621050 citedByCount "21" @default.
• W2042621050 countsByYear W20426210502013 @default.
• W2042621050 countsByYear W20426210502014 @default.
• W2042621050 countsByYear W20426210502015 @default.
• W2042621050 countsByYear W20426210502019 @default.
• W2042621050 countsByYear W20426210502023 @default.
• W2042621050 crossrefType "journal-article" @default.
• W2042621050 hasAuthorship W2042621050A5026013572 @default.
• W2042621050 hasAuthorship W2042621050A5036979193 @default.
• W2042621050 hasAuthorship W2042621050A5089740171 @default.
• W2042621050 hasConcept C126322002 @default.
• W2042621050 hasConcept C134018914 @default.
• W2042621050 hasConcept C155164980 @default.
• W2042621050 hasConcept C158617107 @default.
• W2042621050 hasConcept C162740809 @default.
• W2042621050 hasConcept C167007842 @default.
• W2042621050 hasConcept C170488646 @default.
• W2042621050 hasConcept C170493617 @default.
• W2042621050 hasConcept C185592680 @default.
• W2042621050 hasConcept C2776610495 @default.
• W2042621050 hasConcept C2777022698 @default.
• W2042621050 hasConcept C2777093181 @default.
• W2042621050 hasConcept C2777146706 @default.
• W2042621050 hasConcept C2779996123 @default.
• W2042621050 hasConcept C28406088 @default.
• W2042621050 hasConcept C50254741 @default.
• W2042621050 hasConcept C519063684 @default.
• W2042621050 hasConcept C519581460 @default.
• W2042621050 hasConcept C55493867 @default.
• W2042621050 hasConcept C62478195 @default.
• W2042621050 hasConcept C71924100 @default.
• W2042621050 hasConcept C86803240 @default.
• W2042621050 hasConceptScore W2042621050C126322002 @default.
• W2042621050 hasConceptScore W2042621050C134018914 @default.
• W2042621050 hasConceptScore W2042621050C155164980 @default.
• W2042621050 hasConceptScore W2042621050C158617107 @default.
• W2042621050 hasConceptScore W2042621050C162740809 @default.
• W2042621050 hasConceptScore W2042621050C167007842 @default.
• W2042621050 hasConceptScore W2042621050C170488646 @default.
• W2042621050 hasConceptScore W2042621050C170493617 @default.
• W2042621050 hasConceptScore W2042621050C185592680 @default.
• W2042621050 hasConceptScore W2042621050C2776610495 @default.

• next