FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042631510> ?p ?o ?g. }

• W2042631510 endingPage "e36941" @default.
• W2042631510 startingPage "e36941" @default.
• W2042631510 abstract "Our previous study shows that inhibiting activator protein one (AP1) transcription factor function in murine epidermis, using dominant-negative c-jun (TAM67), increases cell proliferation and delays differentiation. To understand the mechanism of action, we compare TAM67 impact in mouse epidermis and in cultured normal human keratinocytes. We show that TAM67 localizes in the nucleus where it forms TAM67 homodimers that competitively interact with AP1 transcription factor DNA binding sites to reduce endogenous jun and fos factor binding. Involucrin is a marker of keratinocyte differentiation that is expressed in the suprabasal epidermis and this expression requires AP1 factor interaction at the AP1-5 site in the promoter. TAM67 interacts competitively at this site to reduce involucrin expression. TAM67 also reduces endogenous c-jun, junB and junD mRNA and protein level. Studies with c-jun promoter suggest that this is due to reduced transcription of the c-jun gene. We propose that TAM67 suppresses keratinocyte differentiation by interfering with endogenous AP1 factor binding to regulator elements in differentiation-associated target genes, and by reducing endogenous c-jun factor expression." @default.
• W2042631510 created "2016-06-24" @default.
• W2042631510 creator A5000749676 @default.
• W2042631510 creator A5015561283 @default.
• W2042631510 creator A5022063584 @default.
• W2042631510 creator A5035135173 @default.
• W2042631510 creator A5063578838 @default.
• W2042631510 creator A5075659328 @default.
• W2042631510 date "2012-05-23" @default.
• W2042631510 modified "2023-09-24" @default.
• W2042631510 title "Suppression of AP1 Transcription Factor Function in Keratinocyte Suppresses Differentiation" @default.
• W2042631510 cites W1584796599 @default.
• W2042631510 cites W1833690096 @default.
• W2042631510 cites W1965198668 @default.
• W2042631510 cites W1965904488 @default.
• W2042631510 cites W1966163434 @default.
• W2042631510 cites W1966358876 @default.
• W2042631510 cites W1970980596 @default.
• W2042631510 cites W1986135678 @default.
• W2042631510 cites W1987015606 @default.
• W2042631510 cites W1989223059 @default.
• W2042631510 cites W1989510923 @default.
• W2042631510 cites W1991281300 @default.
• W2042631510 cites W1991733505 @default.
• W2042631510 cites W1994219871 @default.
• W2042631510 cites W2001964336 @default.
• W2042631510 cites W2006020460 @default.
• W2042631510 cites W2017528068 @default.
• W2042631510 cites W2018274375 @default.
• W2042631510 cites W2027643111 @default.
• W2042631510 cites W2028753942 @default.
• W2042631510 cites W2032024042 @default.
• W2042631510 cites W2034654881 @default.
• W2042631510 cites W2036224418 @default.
• W2042631510 cites W2037436440 @default.
• W2042631510 cites W2037604903 @default.
• W2042631510 cites W2044375623 @default.
• W2042631510 cites W2045610791 @default.
• W2042631510 cites W2052151382 @default.
• W2042631510 cites W2056837489 @default.
• W2042631510 cites W2061872792 @default.
• W2042631510 cites W2062000450 @default.
• W2042631510 cites W2067728189 @default.
• W2042631510 cites W2068908390 @default.
• W2042631510 cites W2072420580 @default.
• W2042631510 cites W2086880360 @default.
• W2042631510 cites W2087287360 @default.
• W2042631510 cites W2090671871 @default.
• W2042631510 cites W2094872845 @default.
• W2042631510 cites W2095498665 @default.
• W2042631510 cites W2097142088 @default.
• W2042631510 cites W2100837269 @default.
• W2042631510 cites W2126542558 @default.
• W2042631510 cites W2129886268 @default.
• W2042631510 cites W2144183221 @default.
• W2042631510 cites W2145704650 @default.
• W2042631510 cites W2152987051 @default.
• W2042631510 cites W2155152424 @default.
• W2042631510 cites W2157177150 @default.
• W2042631510 cites W2163457900 @default.
• W2042631510 cites W2165064874 @default.
• W2042631510 cites W2165527042 @default.
• W2042631510 cites W2167059316 @default.
• W2042631510 cites W2170213060 @default.
• W2042631510 cites W2172078816 @default.
• W2042631510 cites W2312256607 @default.
• W2042631510 cites W2322523258 @default.
• W2042631510 cites W2342083870 @default.
• W2042631510 doi "https://doi.org/10.1371/journal.pone.0036941" @default.
• W2042631510 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3359321" @default.
• W2042631510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22649503" @default.
• W2042631510 hasPublicationYear "2012" @default.
• W2042631510 type Work @default.
• W2042631510 sameAs 2042631510 @default.
• W2042631510 citedByCount "21" @default.
• W2042631510 countsByYear W20426315102012 @default.
• W2042631510 countsByYear W20426315102013 @default.
• W2042631510 countsByYear W20426315102014 @default.
• W2042631510 countsByYear W20426315102015 @default.
• W2042631510 countsByYear W20426315102016 @default.
• W2042631510 countsByYear W20426315102017 @default.
• W2042631510 countsByYear W20426315102019 @default.
• W2042631510 countsByYear W20426315102021 @default.
• W2042631510 crossrefType "journal-article" @default.
• W2042631510 hasAuthorship W2042631510A5000749676 @default.
• W2042631510 hasAuthorship W2042631510A5015561283 @default.
• W2042631510 hasAuthorship W2042631510A5022063584 @default.
• W2042631510 hasAuthorship W2042631510A5035135173 @default.
• W2042631510 hasAuthorship W2042631510A5063578838 @default.
• W2042631510 hasAuthorship W2042631510A5075659328 @default.
• W2042631510 hasBestOaLocation W20426315101 @default.
• W2042631510 hasConcept C102280478 @default.
• W2042631510 hasConcept C104317684 @default.
• W2042631510 hasConcept C153911025 @default.
• W2042631510 hasConcept C2777074287 @default.
• W2042631510 hasConcept C2777577635 @default.
• W2042631510 hasConcept C2781085546 @default.
• W2042631510 hasConcept C54355233 @default.

• next