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• W2042642145 abstract "Abstract We have identified a novel mature human B-cell subpopulation in the human tonsil that has characteristics of both naive B cells and germinal center B cells including the expression of activation-induced cytidine deaminase (AID), which is essential for the process of immunoglobulin somatic hypermutation and class-switch recombination. These cells are clearly somatically hypermutated, albeit modestly. Their phenotype (IgD+CD38−CD23−FSChiCD71+) is unique and suggests they may be intermediate between both naive and germinal center cells. Morphologically they are also distinct from other B-cell subpopulations. The evidence presented suggests these cells may be the founder cells of the germinal center reaction (a pro-GC cell) and may be the normal counterpart of the mantle cell lymphoma cell." @default.
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• W2042642145 date "2006-11-28" @default.
• W2042642145 modified "2023-10-16" @default.
• W2042642145 title "A novel human B cell subpopulation representing the initial germinal center population to express AID" @default.
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• W2042642145 doi "https://doi.org/10.1182/blood-2006-07-037150" @default.
• W2042642145 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1852199" @default.
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