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• W2042664299 abstract "Here we describe a simple, stable, and specific gas chromatography-mass spectrometry (GC-MS) method for the determination of nevirapine in plasma. After precipitation of proteins, the non-nucleoside reverse transcriptase inhibitor nevirapine was extracted with dichloromethane. For the determination and quantification of nevirapine, 1 microL of the organic layer was injected onto the GC-MS system. Linear calibration curves were obtained with BIRH 0414BS as internal standard in a range from 0.01 to 15 microg/mL. Intra- and inter-day accuracy and precision of this method were good with an accuracy between 96-109% and a precision between 2-8% across the therapeutic range of nevirapine. GC-MS proved to be a valid alternative to high-performance liquid chromatography and liquid chromatography-MS." @default.
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• W2042664299 date "2010-02-01" @default.
• W2042664299 modified "2023-10-18" @default.
• W2042664299 title "Determination of Nevirapine in Plasma by GC-MS" @default.
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• W2042664299 doi "https://doi.org/10.1093/chromsci/48.2.91" @default.
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