FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042683670> ?p ?o ?g. }

• W2042683670 endingPage "433" @default.
• W2042683670 startingPage "420" @default.
• W2042683670 abstract "The number of recovered lymph nodes is associated with good prognosis among colon cancer patients undergoing surgical resection. However, little has been known on prognostic significance of lymph node count after adjusting for host immune response to tumor and tumoral molecular alterations, both of which are associated with the lymph node count and patient survival.Among 716 colorectal cancers (stages 1-4) in two independent prospective cohorts, we examined patient survival in relation to the negative lymph node count and lymph node ratio (LNR; positive to total lymph node counts). Cox proportional hazard models were used to compute hazard ratio of deaths, adjusted for patient, specimen, and tumoral characteristics, including lymphocytic reactions, KRAS and BRAF mutations, p53 expression, microsatellite instability (MSI), the CpG island methylator phenotype (CIMP), and LINE-1 methylation.Compared with patients with 0-3 negative lymph nodes, patients with 7-12 and > or =13 negative nodes experienced a significant reduction in cancer-specific and overall mortality in Kaplan-Meier analysis (log-rank P<0.0001), univariate Cox regression (P(trend)<0.0001), and multivariate analysis (P(trend)<0.0003), independent of potential confounders examined. The benefit associated with the negative node count was apparent across all stages, although the effect was significantly greater in stages 1-2 than stages 3-4 (P(interaction)=0.002). In both stage 3 and stage 4, smaller LNR was associated with improved survival (log-rank P<0.0001).The negative lymph node count is associated with improved survival of colorectal cancer patients, independent of lymphocytic reactions to tumor and tumoral molecular features including MSI, CIMP, LINE-1 hypomethylation and BRAF mutation." @default.
• W2042683670 created "2016-06-24" @default.
• W2042683670 creator A5004733324 @default.
• W2042683670 creator A5011491566 @default.
• W2042683670 creator A5018121170 @default.
• W2042683670 creator A5027170448 @default.
• W2042683670 creator A5038373228 @default.
• W2042683670 creator A5049314303 @default.
• W2042683670 creator A5057394943 @default.
• W2042683670 creator A5069774184 @default.
• W2042683670 creator A5072389805 @default.
• W2042683670 creator A5076818447 @default.
• W2042683670 date "2010-02-01" @default.
• W2042683670 modified "2023-10-18" @default.
• W2042683670 title "Negative Lymph Node Count Is Associated With Survival of Colorectal Cancer Patients, Independent of Tumoral Molecular Alterations and Lymphocytic Reaction" @default.
• W2042683670 cites W1965301144 @default.
• W2042683670 cites W1971937022 @default.
• W2042683670 cites W1973402430 @default.
• W2042683670 cites W1975224807 @default.
• W2042683670 cites W1976974072 @default.
• W2042683670 cites W1993965603 @default.
• W2042683670 cites W1996204856 @default.
• W2042683670 cites W1997125643 @default.
• W2042683670 cites W1997860952 @default.
• W2042683670 cites W1998677519 @default.
• W2042683670 cites W2001517273 @default.
• W2042683670 cites W2007420407 @default.
• W2042683670 cites W2008762740 @default.
• W2042683670 cites W2008848534 @default.
• W2042683670 cites W2009809283 @default.
• W2042683670 cites W2009811888 @default.
• W2042683670 cites W2011785751 @default.
• W2042683670 cites W2018679072 @default.
• W2042683670 cites W2023473560 @default.
• W2042683670 cites W2026680808 @default.
• W2042683670 cites W2033689666 @default.
• W2042683670 cites W2037952228 @default.
• W2042683670 cites W2043564561 @default.
• W2042683670 cites W2044765083 @default.
• W2042683670 cites W2048159798 @default.
• W2042683670 cites W2049456131 @default.
• W2042683670 cites W2064854706 @default.
• W2042683670 cites W2068112058 @default.
• W2042683670 cites W2068304684 @default.
• W2042683670 cites W2069663898 @default.
• W2042683670 cites W2081905918 @default.
• W2042683670 cites W2084469088 @default.
• W2042683670 cites W2090300131 @default.
• W2042683670 cites W2096151993 @default.
• W2042683670 cites W2098787760 @default.
• W2042683670 cites W2105307866 @default.
• W2042683670 cites W2108290753 @default.
• W2042683670 cites W2122870672 @default.
• W2042683670 cites W2123636561 @default.
• W2042683670 cites W2124841274 @default.
• W2042683670 cites W2126116106 @default.
• W2042683670 cites W2150269898 @default.
• W2042683670 cites W2152851361 @default.
• W2042683670 cites W2156409297 @default.
• W2042683670 cites W2160598672 @default.
• W2042683670 cites W2166436294 @default.
• W2042683670 cites W2168111444 @default.
• W2042683670 cites W2169903102 @default.
• W2042683670 doi "https://doi.org/10.1038/ajg.2009.578" @default.
• W2042683670 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2878181" @default.
• W2042683670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19809407" @default.
• W2042683670 hasPublicationYear "2010" @default.
• W2042683670 type Work @default.
• W2042683670 sameAs 2042683670 @default.
• W2042683670 citedByCount "71" @default.
• W2042683670 countsByYear W20426836702012 @default.
• W2042683670 countsByYear W20426836702013 @default.
• W2042683670 countsByYear W20426836702014 @default.
• W2042683670 countsByYear W20426836702015 @default.
• W2042683670 countsByYear W20426836702016 @default.
• W2042683670 countsByYear W20426836702017 @default.
• W2042683670 countsByYear W20426836702018 @default.
• W2042683670 countsByYear W20426836702019 @default.
• W2042683670 countsByYear W20426836702020 @default.
• W2042683670 countsByYear W20426836702021 @default.
• W2042683670 countsByYear W20426836702022 @default.
• W2042683670 countsByYear W20426836702023 @default.
• W2042683670 crossrefType "journal-article" @default.
• W2042683670 hasAuthorship W2042683670A5004733324 @default.
• W2042683670 hasAuthorship W2042683670A5011491566 @default.
• W2042683670 hasAuthorship W2042683670A5018121170 @default.
• W2042683670 hasAuthorship W2042683670A5027170448 @default.
• W2042683670 hasAuthorship W2042683670A5038373228 @default.
• W2042683670 hasAuthorship W2042683670A5049314303 @default.
• W2042683670 hasAuthorship W2042683670A5057394943 @default.
• W2042683670 hasAuthorship W2042683670A5069774184 @default.
• W2042683670 hasAuthorship W2042683670A5072389805 @default.
• W2042683670 hasAuthorship W2042683670A5076818447 @default.
• W2042683670 hasBestOaLocation W20426836702 @default.
• W2042683670 hasConcept C10515644 @default.
• W2042683670 hasConcept C121608353 @default.
• W2042683670 hasConcept C126322002 @default.
• W2042683670 hasConcept C142724271 @default.

• next