Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042687127> ?p ?o ?g. }
- W2042687127 endingPage "289" @default.
- W2042687127 startingPage "284" @default.
- W2042687127 abstract "We have previously described a T helper cell 2-type clone, A3, of rat T cells that provides help for antibody production to Actinobacillus actinomycetemcomitans in vitro and in vivo in normal (euthymic) isogeneic Rowett strain recipient rats. Adoptive transfer of this T helper cell clone to euthymic rats also protects them from periodontal bone loss induced by oral infection with A. actinomycetemcomitans. In the present study, to assess the cell requirement for protection, A3 clone T lymphocytes (106) or naive lymph node (6 × 104) T cells, or A3 plus naive lymph node T cells (6 × 104) were adoptively transferred to groups (n= 7–9) of 30-day-old Rowett athymic nude (rnu/rnu) rats. All recipients were also immunized (intraperitoneally) with 107 killed A. actinomycetemcomitans on the day of T cell transfer and orally infected with these bacteria on each of the next 5 days. Recipients of the combined A3 + lymph node T cell transfer showed significantly increased serum immunoglobulin G (IgG) and IgM antibody to A. actinomycetemcomitans and in vitro proliferation of spleen lymphocytes to A. actinomycetemcomitans as antigen compared with nude animals receiving lymph node T cells only. Although other possibilities are discussed, we inferred that these differences might be due to successful population of the congenitally athymic rats by A3 clone cells given with a small number of normal autologous naive lymph node T cells. The result of this co-transfer of naive T cells with the A3 clone cells seemed to be greatly increased antibody production and protection from periodontal bone loss." @default.
- W2042687127 created "2016-06-24" @default.
- W2042687127 creator A5003207744 @default.
- W2042687127 creator A5014395259 @default.
- W2042687127 creator A5021642187 @default.
- W2042687127 creator A5053035402 @default.
- W2042687127 creator A5056136715 @default.
- W2042687127 date "1994-10-01" @default.
- W2042687127 modified "2023-10-13" @default.
- W2042687127 title "Adoptive transfer of cloned T helper cells ameliorates periodontal disease in nude rats" @default.
- W2042687127 cites W1542022631 @default.
- W2042687127 cites W1830061030 @default.
- W2042687127 cites W1881010940 @default.
- W2042687127 cites W1904165260 @default.
- W2042687127 cites W1912302551 @default.
- W2042687127 cites W1976213001 @default.
- W2042687127 cites W1995467776 @default.
- W2042687127 cites W1995597174 @default.
- W2042687127 cites W2006933524 @default.
- W2042687127 cites W2022800344 @default.
- W2042687127 cites W2043759777 @default.
- W2042687127 cites W2053922350 @default.
- W2042687127 cites W2077003421 @default.
- W2042687127 cites W2083185383 @default.
- W2042687127 cites W2091507184 @default.
- W2042687127 cites W2108192378 @default.
- W2042687127 cites W2117168319 @default.
- W2042687127 cites W2130207696 @default.
- W2042687127 cites W2132008851 @default.
- W2042687127 cites W2141460230 @default.
- W2042687127 cites W2170206314 @default.
- W2042687127 cites W2300579674 @default.
- W2042687127 cites W2782495463 @default.
- W2042687127 doi "https://doi.org/10.1111/j.1399-302x.1994.tb00072.x" @default.
- W2042687127 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7808770" @default.
- W2042687127 hasPublicationYear "1994" @default.
- W2042687127 type Work @default.
- W2042687127 sameAs 2042687127 @default.
- W2042687127 citedByCount "67" @default.
- W2042687127 countsByYear W20426871272012 @default.
- W2042687127 countsByYear W20426871272013 @default.
- W2042687127 countsByYear W20426871272014 @default.
- W2042687127 countsByYear W20426871272015 @default.
- W2042687127 countsByYear W20426871272016 @default.
- W2042687127 countsByYear W20426871272017 @default.
- W2042687127 countsByYear W20426871272018 @default.
- W2042687127 crossrefType "journal-article" @default.
- W2042687127 hasAuthorship W2042687127A5003207744 @default.
- W2042687127 hasAuthorship W2042687127A5014395259 @default.
- W2042687127 hasAuthorship W2042687127A5021642187 @default.
- W2042687127 hasAuthorship W2042687127A5053035402 @default.
- W2042687127 hasAuthorship W2042687127A5056136715 @default.
- W2042687127 hasConcept C142724271 @default.
- W2042687127 hasConcept C147483822 @default.
- W2042687127 hasConcept C154317977 @default.
- W2042687127 hasConcept C159654299 @default.
- W2042687127 hasConcept C202751555 @default.
- W2042687127 hasConcept C203014093 @default.
- W2042687127 hasConcept C2776090121 @default.
- W2042687127 hasConcept C2779720271 @default.
- W2042687127 hasConcept C2780849966 @default.
- W2042687127 hasConcept C2780931953 @default.
- W2042687127 hasConcept C2781136212 @default.
- W2042687127 hasConcept C2908647359 @default.
- W2042687127 hasConcept C54355233 @default.
- W2042687127 hasConcept C552990157 @default.
- W2042687127 hasConcept C55493867 @default.
- W2042687127 hasConcept C71924100 @default.
- W2042687127 hasConcept C81089528 @default.
- W2042687127 hasConcept C86803240 @default.
- W2042687127 hasConcept C8891405 @default.
- W2042687127 hasConcept C90375314 @default.
- W2042687127 hasConcept C99454951 @default.
- W2042687127 hasConceptScore W2042687127C142724271 @default.
- W2042687127 hasConceptScore W2042687127C147483822 @default.
- W2042687127 hasConceptScore W2042687127C154317977 @default.
- W2042687127 hasConceptScore W2042687127C159654299 @default.
- W2042687127 hasConceptScore W2042687127C202751555 @default.
- W2042687127 hasConceptScore W2042687127C203014093 @default.
- W2042687127 hasConceptScore W2042687127C2776090121 @default.
- W2042687127 hasConceptScore W2042687127C2779720271 @default.
- W2042687127 hasConceptScore W2042687127C2780849966 @default.
- W2042687127 hasConceptScore W2042687127C2780931953 @default.
- W2042687127 hasConceptScore W2042687127C2781136212 @default.
- W2042687127 hasConceptScore W2042687127C2908647359 @default.
- W2042687127 hasConceptScore W2042687127C54355233 @default.
- W2042687127 hasConceptScore W2042687127C552990157 @default.
- W2042687127 hasConceptScore W2042687127C55493867 @default.
- W2042687127 hasConceptScore W2042687127C71924100 @default.
- W2042687127 hasConceptScore W2042687127C81089528 @default.
- W2042687127 hasConceptScore W2042687127C86803240 @default.
- W2042687127 hasConceptScore W2042687127C8891405 @default.
- W2042687127 hasConceptScore W2042687127C90375314 @default.
- W2042687127 hasConceptScore W2042687127C99454951 @default.
- W2042687127 hasIssue "5" @default.
- W2042687127 hasLocation W20426871271 @default.
- W2042687127 hasLocation W20426871272 @default.
- W2042687127 hasOpenAccess W2042687127 @default.