Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042700972> ?p ?o ?g. }
- W2042700972 endingPage "491" @default.
- W2042700972 startingPage "483" @default.
- W2042700972 abstract "Neurofibromatosis type 2 (NF2) is an autosomal dominant disease that is characterized mainly by schwannomas, as well as menigiomas and gliomas. The NF2 gene product merlin/schwannomin acts as a tumor suppressor. Schwann cells derived from NF2 schwannomas showed an enhanced proliferation rate, and electrophysological studies revealed larger K(+) outward currents as compared with controls. Schwann cells isolated from schwannomas of NF2 patients or multiorgan donors were treated with different concentrations of the K(+) current blockers quinidine, tetraethylammonium chloride, and 4-aminopyridine and K(+) outward currents and proliferation rates of these cells were compared. K(+) outward currents of both cell types can be blocked by quinidine. Importantly, treatment with quinidine reduces proliferation of NF2 Schwann cells in a concentration dependent manner but did not reduce proliferation of normal Schwann cells. Therefore, the use of quinidine or quinidine-like components would possibly provide a novel adjuvant therapeutic option for NF2 patients to slow down or freeze growth of schwannomas." @default.
- W2042700972 created "2016-06-24" @default.
- W2042700972 creator A5006577362 @default.
- W2042700972 creator A5009672080 @default.
- W2042700972 creator A5010196429 @default.
- W2042700972 creator A5016807932 @default.
- W2042700972 creator A5045353364 @default.
- W2042700972 creator A5048730674 @default.
- W2042700972 creator A5058868661 @default.
- W2042700972 date "2000-08-01" @default.
- W2042700972 modified "2023-09-27" @default.
- W2042700972 title "Enhanced Proliferation and Potassium Conductance of Schwann Cells Isolated from NF2 Schwannomas Can Be Reduced by Quinidine" @default.
- W2042700972 cites W1495670687 @default.
- W2042700972 cites W1976194286 @default.
- W2042700972 cites W1992517154 @default.
- W2042700972 cites W1995263093 @default.
- W2042700972 cites W1995965267 @default.
- W2042700972 cites W1996736723 @default.
- W2042700972 cites W1998852147 @default.
- W2042700972 cites W2004947583 @default.
- W2042700972 cites W2009667219 @default.
- W2042700972 cites W2023247590 @default.
- W2042700972 cites W2029976610 @default.
- W2042700972 cites W2040963497 @default.
- W2042700972 cites W2043744055 @default.
- W2042700972 cites W2046472496 @default.
- W2042700972 cites W2048140690 @default.
- W2042700972 cites W2049035037 @default.
- W2042700972 cites W2050877691 @default.
- W2042700972 cites W2054582519 @default.
- W2042700972 cites W2060655307 @default.
- W2042700972 cites W2070452292 @default.
- W2042700972 cites W2071456395 @default.
- W2042700972 cites W2077858999 @default.
- W2042700972 cites W2088774665 @default.
- W2042700972 cites W2090040363 @default.
- W2042700972 cites W2093755147 @default.
- W2042700972 cites W2100868490 @default.
- W2042700972 cites W2100959692 @default.
- W2042700972 cites W2102655738 @default.
- W2042700972 cites W2105994616 @default.
- W2042700972 cites W2107503430 @default.
- W2042700972 cites W2161655320 @default.
- W2042700972 cites W2161807488 @default.
- W2042700972 cites W2315552227 @default.
- W2042700972 cites W2330005549 @default.
- W2042700972 cites W2413031453 @default.
- W2042700972 doi "https://doi.org/10.1006/nbdi.2000.0307" @default.
- W2042700972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10964617" @default.
- W2042700972 hasPublicationYear "2000" @default.
- W2042700972 type Work @default.
- W2042700972 sameAs 2042700972 @default.
- W2042700972 citedByCount "15" @default.
- W2042700972 countsByYear W20427009722013 @default.
- W2042700972 countsByYear W20427009722014 @default.
- W2042700972 crossrefType "journal-article" @default.
- W2042700972 hasAuthorship W2042700972A5006577362 @default.
- W2042700972 hasAuthorship W2042700972A5009672080 @default.
- W2042700972 hasAuthorship W2042700972A5010196429 @default.
- W2042700972 hasAuthorship W2042700972A5016807932 @default.
- W2042700972 hasAuthorship W2042700972A5045353364 @default.
- W2042700972 hasAuthorship W2042700972A5048730674 @default.
- W2042700972 hasAuthorship W2042700972A5058868661 @default.
- W2042700972 hasConcept C121608353 @default.
- W2042700972 hasConcept C126322002 @default.
- W2042700972 hasConcept C134018914 @default.
- W2042700972 hasConcept C178628643 @default.
- W2042700972 hasConcept C179185449 @default.
- W2042700972 hasConcept C185592680 @default.
- W2042700972 hasConcept C2777004073 @default.
- W2042700972 hasConcept C2780339425 @default.
- W2042700972 hasConcept C2780922449 @default.
- W2042700972 hasConcept C502942594 @default.
- W2042700972 hasConcept C55493867 @default.
- W2042700972 hasConcept C62112901 @default.
- W2042700972 hasConcept C71924100 @default.
- W2042700972 hasConcept C83743174 @default.
- W2042700972 hasConcept C86803240 @default.
- W2042700972 hasConcept C95444343 @default.
- W2042700972 hasConcept C98274493 @default.
- W2042700972 hasConceptScore W2042700972C121608353 @default.
- W2042700972 hasConceptScore W2042700972C126322002 @default.
- W2042700972 hasConceptScore W2042700972C134018914 @default.
- W2042700972 hasConceptScore W2042700972C178628643 @default.
- W2042700972 hasConceptScore W2042700972C179185449 @default.
- W2042700972 hasConceptScore W2042700972C185592680 @default.
- W2042700972 hasConceptScore W2042700972C2777004073 @default.
- W2042700972 hasConceptScore W2042700972C2780339425 @default.
- W2042700972 hasConceptScore W2042700972C2780922449 @default.
- W2042700972 hasConceptScore W2042700972C502942594 @default.
- W2042700972 hasConceptScore W2042700972C55493867 @default.
- W2042700972 hasConceptScore W2042700972C62112901 @default.
- W2042700972 hasConceptScore W2042700972C71924100 @default.
- W2042700972 hasConceptScore W2042700972C83743174 @default.
- W2042700972 hasConceptScore W2042700972C86803240 @default.
- W2042700972 hasConceptScore W2042700972C95444343 @default.
- W2042700972 hasConceptScore W2042700972C98274493 @default.
- W2042700972 hasIssue "4" @default.