Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042706065> ?p ?o ?g. }
- W2042706065 endingPage "2140" @default.
- W2042706065 startingPage "2131" @default.
- W2042706065 abstract "Objective— Although the connection of oxidative stress and inflammation has been long recognized in diabetes mellitus, the underlying mechanisms are not fully elucidated. This study defined the role of 26S proteasomes in promoting vascular inflammatory response in early diabetes mellitus. Methods and Results— The 26S proteasome functionality, markers of autophagy, and unfolded protein response were assessed in (1) cultured 26S proteasome reporter cells and endothelial cells challenged with high glucose, (2) transgenic reporter (Ub G76V –green fluorescence protein) and wild-type (C57BL/6J) mice rendered diabetic, and (3) genetically diabetic (Akita and OVE26) mice. In glucose-challenged cells, and also in aortic, renal, and retinal tissues from diabetic mice, enhanced 26S proteasome functionality was observed, evidenced by augmentation of proteasome (chymotrypsin-like) activities and reduction in 26S proteasome reporter proteins, accompanied by increased nitrotyrosine-containing proteins. Also, whereas inhibitor of the nuclear factor κ-light-chain-enhancer of activated B cells α proteins were decreased, an increase was found in nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) nucleus translocation, which enhanced the NF-κB–mediated proinflammatory response, without affecting markers of autophagy or unfolded protein response. Importantly, the alterations were abolished by MG132 administration, small interfering RNA knockdown of PA700 (proteasome activator protein complex), or superoxide scavenging in vivo. Conclusion— Early hyperglycemia enhances 26S proteasome functionality, not autophagy or unfolded protein response, through peroxynitrite/superoxide-mediated PA700-dependent proteasomal activation, which elevates NF- ĸB-mediated endothelial inflammatory response in early diabetes mellitus." @default.
- W2042706065 created "2016-06-24" @default.
- W2042706065 creator A5017285695 @default.
- W2042706065 creator A5069988397 @default.
- W2042706065 creator A5073224882 @default.
- W2042706065 creator A5079417201 @default.
- W2042706065 date "2012-09-01" @default.
- W2042706065 modified "2023-10-16" @default.
- W2042706065 title "Enhancement of 26S Proteasome Functionality Connects Oxidative Stress and Vascular Endothelial Inflammatory Response in Diabetes Mellitus" @default.
- W2042706065 cites W1570610869 @default.
- W2042706065 cites W1708445842 @default.
- W2042706065 cites W180281116 @default.
- W2042706065 cites W1851733051 @default.
- W2042706065 cites W1965140020 @default.
- W2042706065 cites W1973595217 @default.
- W2042706065 cites W1974162725 @default.
- W2042706065 cites W1976616659 @default.
- W2042706065 cites W1979069114 @default.
- W2042706065 cites W1987692790 @default.
- W2042706065 cites W1995805772 @default.
- W2042706065 cites W1997220465 @default.
- W2042706065 cites W1997369314 @default.
- W2042706065 cites W2008424074 @default.
- W2042706065 cites W2016766601 @default.
- W2042706065 cites W2016976370 @default.
- W2042706065 cites W2018076136 @default.
- W2042706065 cites W2021329972 @default.
- W2042706065 cites W2022387682 @default.
- W2042706065 cites W2027435290 @default.
- W2042706065 cites W2028318264 @default.
- W2042706065 cites W2029442790 @default.
- W2042706065 cites W2035892035 @default.
- W2042706065 cites W2038753750 @default.
- W2042706065 cites W2040754116 @default.
- W2042706065 cites W2049399172 @default.
- W2042706065 cites W2051831012 @default.
- W2042706065 cites W2064119981 @default.
- W2042706065 cites W2064394604 @default.
- W2042706065 cites W2067704741 @default.
- W2042706065 cites W2079852736 @default.
- W2042706065 cites W2089743544 @default.
- W2042706065 cites W2089934054 @default.
- W2042706065 cites W2090194051 @default.
- W2042706065 cites W2091709423 @default.
- W2042706065 cites W2099026216 @default.
- W2042706065 cites W2104782188 @default.
- W2042706065 cites W2105729193 @default.
- W2042706065 cites W2105731956 @default.
- W2042706065 cites W2107923493 @default.
- W2042706065 cites W2111524632 @default.
- W2042706065 cites W2114451632 @default.
- W2042706065 cites W2115068194 @default.
- W2042706065 cites W2118886709 @default.
- W2042706065 cites W2124143237 @default.
- W2042706065 cites W2124789042 @default.
- W2042706065 cites W2129674014 @default.
- W2042706065 cites W2134254489 @default.
- W2042706065 cites W2146354558 @default.
- W2042706065 cites W2150367899 @default.
- W2042706065 cites W2152119141 @default.
- W2042706065 cites W2153876494 @default.
- W2042706065 cites W2160652387 @default.
- W2042706065 cites W2162583612 @default.
- W2042706065 cites W2166987747 @default.
- W2042706065 cites W2170971873 @default.
- W2042706065 cites W2171411731 @default.
- W2042706065 cites W2175093343 @default.
- W2042706065 cites W37351408 @default.
- W2042706065 doi "https://doi.org/10.1161/atvbaha.112.253385" @default.
- W2042706065 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3432586" @default.
- W2042706065 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22772755" @default.
- W2042706065 hasPublicationYear "2012" @default.
- W2042706065 type Work @default.
- W2042706065 sameAs 2042706065 @default.
- W2042706065 citedByCount "51" @default.
- W2042706065 countsByYear W20427060652013 @default.
- W2042706065 countsByYear W20427060652014 @default.
- W2042706065 countsByYear W20427060652015 @default.
- W2042706065 countsByYear W20427060652016 @default.
- W2042706065 countsByYear W20427060652017 @default.
- W2042706065 countsByYear W20427060652018 @default.
- W2042706065 countsByYear W20427060652019 @default.
- W2042706065 countsByYear W20427060652020 @default.
- W2042706065 countsByYear W20427060652021 @default.
- W2042706065 countsByYear W20427060652022 @default.
- W2042706065 countsByYear W20427060652023 @default.
- W2042706065 crossrefType "journal-article" @default.
- W2042706065 hasAuthorship W2042706065A5017285695 @default.
- W2042706065 hasAuthorship W2042706065A5069988397 @default.
- W2042706065 hasAuthorship W2042706065A5073224882 @default.
- W2042706065 hasAuthorship W2042706065A5079417201 @default.
- W2042706065 hasBestOaLocation W20427060652 @default.
- W2042706065 hasConcept C134018914 @default.
- W2042706065 hasConcept C139447449 @default.
- W2042706065 hasConcept C158617107 @default.
- W2042706065 hasConcept C164027704 @default.
- W2042706065 hasConcept C185592680 @default.
- W2042706065 hasConcept C187436293 @default.