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• W2042719197 abstract "The synthesis of a number of 1,4-bis(amino)anthracene-9,10-diones containing chlorine or sulfur which are related to the anti-cancer drugs Ametantrone and Mitoxantrone are reported. 1,4-Dichloro-2,3-dihydro-5,8-dihydroxyanthracene-9,10-dione reacts readily with a series of alkylamines to yield the corresponding 1,4-bis(alkylamino)-5,8-dichloroanthracene-9,10-dione after oxidation. The subsequent reaction of the products with ethanethiol or thiophenol gives the corresponding 1,4-bis(alkylamino)-5,8-bis(sulfanyl)anthracene-9,10-dione in good yield. Theoretical calculations at the RHF 6-31G** level indicate that the introduction of either chlorine or the phenylsulfanyl group into the 5- and 8-positions of 1,4-bis(alkylamino)anthracene-9,10-diones results in a lowering of the LUMO energies suggesting that related functionalised derivatives might have lower cardiotoxicities than Mitoxantrone." @default.
• W2042719197 created "2016-06-24" @default.
• W2042719197 creator A5028468427 @default.
• W2042719197 creator A5030970462 @default.
• W2042719197 date "2006-01-01" @default.
• W2042719197 modified "2023-09-27" @default.
• W2042719197 title "Synthesis and calculated properties of some 1,4-bis(amino)anthracene-9,10-diones" @default.
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• W2042719197 doi "https://doi.org/10.1039/b610625k" @default.
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