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• W2042729953 abstract "We hypothesize a sequential program of expression of the leukocyte-receptor complex (LRC) in CD8+T cells, associated with cellular activation and the subsequent establishment of immune homeostasis through resistance to apoptosis. This program, which is consistent with the linear development of memory CD8+ T cells, represents an ordered expression of genes during differentiation, analogous to expression of the homeobox- or globin-gene clusters. Our model not only has implications for the development and maintenance of T-cell memory but also, relates to the formation of LRC repertoires in other cell types, particularly, the development of killer-cell Ig-like receptor (KIR) repertoires in natural-killer-cell precursors." @default.
• W2042729953 created "2016-06-24" @default.
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• W2042729953 date "2002-02-01" @default.
• W2042729953 modified "2023-09-26" @default.
• W2042729953 title "KIR expression shapes cytotoxic repertoires: a developmental program of survival" @default.
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• W2042729953 doi "https://doi.org/10.1016/s1471-4906(01)02113-5" @default.
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