FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042738496> ?p ?o ?g. }

• W2042738496 endingPage "7237" @default.
• W2042738496 startingPage "7226" @default.
• W2042738496 abstract "Members of the large aggregating chondroitin sulfate proteoglycans are characterized by an N-terminal fragment known as G1 domain, which is composed of an immunoglobulin (IgG)-like motif and two tandem repeats (TR). Previous studies have indicated that the expressed product of aggrecan G1 domain was not secreted. Here we demonstrated that the inability of G1 secretion was associated with the tandem repeats but not the IgG-like motif, and specifically with TR1 of aggrecan. We also demonstrated that the G2 domain, a domain unique to aggrecan, had a similar effect on product secretion. The sequence of TR1 of G1 is highly conserved across species, which suggested similar functions played by these motifs. In a yeast two-hybrid assay, TR1 interacted with the calcium homeostasis endoplasmic reticulum protein. Deletion/mutation experiments indicated that the N-terminal fragment of TR1, in particular, the amino acids H2R4 of this motif were key to its effect on product secretion. However, the N-terminal 55 amino acids were required to exert this function. Taken together, our study suggests a possible molecular mechanism for the function of the tandem repeats in product processing." @default.
• W2042738496 created "2016-06-24" @default.
• W2042738496 creator A5014431860 @default.
• W2042738496 creator A5028932344 @default.
• W2042738496 creator A5039200976 @default.
• W2042738496 creator A5048751010 @default.
• W2042738496 creator A5049209739 @default.
• W2042738496 creator A5056309387 @default.
• W2042738496 creator A5063034183 @default.
• W2042738496 creator A5063942792 @default.
• W2042738496 creator A5064715130 @default.
• W2042738496 creator A5084204673 @default.
• W2042738496 date "2003-05-20" @default.
• W2042738496 modified "2023-09-23" @default.
• W2042738496 title "Identification of the Motifs and Amino Acids in Aggrecan G1 and G2 Domains Involved in Product Secretion†" @default.
• W2042738496 cites W1486203466 @default.
• W2042738496 cites W1512696618 @default.
• W2042738496 cites W1521949639 @default.
• W2042738496 cites W1531779321 @default.
• W2042738496 cites W1554238701 @default.
• W2042738496 cites W1605448867 @default.
• W2042738496 cites W1712774648 @default.
• W2042738496 cites W1751400903 @default.
• W2042738496 cites W1945897416 @default.
• W2042738496 cites W1970127647 @default.
• W2042738496 cites W1981586180 @default.
• W2042738496 cites W2054500578 @default.
• W2042738496 cites W2080270214 @default.
• W2042738496 cites W2114769400 @default.
• W2042738496 cites W2131480836 @default.
• W2042738496 cites W2335897943 @default.
• W2042738496 cites W2337841392 @default.
• W2042738496 cites W4240561424 @default.
• W2042738496 cites W5695444 @default.
• W2042738496 doi "https://doi.org/10.1021/bi027241z" @default.
• W2042738496 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12795619" @default.
• W2042738496 hasPublicationYear "2003" @default.
• W2042738496 type Work @default.
• W2042738496 sameAs 2042738496 @default.
• W2042738496 citedByCount "12" @default.
• W2042738496 countsByYear W20427384962013 @default.
• W2042738496 countsByYear W20427384962014 @default.
• W2042738496 crossrefType "journal-article" @default.
• W2042738496 hasAuthorship W2042738496A5014431860 @default.
• W2042738496 hasAuthorship W2042738496A5028932344 @default.
• W2042738496 hasAuthorship W2042738496A5039200976 @default.
• W2042738496 hasAuthorship W2042738496A5048751010 @default.
• W2042738496 hasAuthorship W2042738496A5049209739 @default.
• W2042738496 hasAuthorship W2042738496A5056309387 @default.
• W2042738496 hasAuthorship W2042738496A5063034183 @default.
• W2042738496 hasAuthorship W2042738496A5063942792 @default.
• W2042738496 hasAuthorship W2042738496A5064715130 @default.
• W2042738496 hasAuthorship W2042738496A5084204673 @default.
• W2042738496 hasConcept C104317684 @default.
• W2042738496 hasConcept C141231307 @default.
• W2042738496 hasConcept C142724271 @default.
• W2042738496 hasConcept C156399914 @default.
• W2042738496 hasConcept C158617107 @default.
• W2042738496 hasConcept C185592680 @default.
• W2042738496 hasConcept C197534660 @default.
• W2042738496 hasConcept C204787440 @default.
• W2042738496 hasConcept C27149982 @default.
• W2042738496 hasConcept C2776164576 @default.
• W2042738496 hasConcept C3020332539 @default.
• W2042738496 hasConcept C49039625 @default.
• W2042738496 hasConcept C515207424 @default.
• W2042738496 hasConcept C55493867 @default.
• W2042738496 hasConcept C71924100 @default.
• W2042738496 hasConcept C86803240 @default.
• W2042738496 hasConcept C95444343 @default.
• W2042738496 hasConceptScore W2042738496C104317684 @default.
• W2042738496 hasConceptScore W2042738496C141231307 @default.
• W2042738496 hasConceptScore W2042738496C142724271 @default.
• W2042738496 hasConceptScore W2042738496C156399914 @default.
• W2042738496 hasConceptScore W2042738496C158617107 @default.
• W2042738496 hasConceptScore W2042738496C185592680 @default.
• W2042738496 hasConceptScore W2042738496C197534660 @default.
• W2042738496 hasConceptScore W2042738496C204787440 @default.
• W2042738496 hasConceptScore W2042738496C27149982 @default.
• W2042738496 hasConceptScore W2042738496C2776164576 @default.
• W2042738496 hasConceptScore W2042738496C3020332539 @default.
• W2042738496 hasConceptScore W2042738496C49039625 @default.
• W2042738496 hasConceptScore W2042738496C515207424 @default.
• W2042738496 hasConceptScore W2042738496C55493867 @default.
• W2042738496 hasConceptScore W2042738496C71924100 @default.
• W2042738496 hasConceptScore W2042738496C86803240 @default.
• W2042738496 hasConceptScore W2042738496C95444343 @default.
• W2042738496 hasIssue "23" @default.
• W2042738496 hasLocation W20427384961 @default.
• W2042738496 hasLocation W20427384962 @default.
• W2042738496 hasOpenAccess W2042738496 @default.
• W2042738496 hasPrimaryLocation W20427384961 @default.
• W2042738496 hasRelatedWork W1866025165 @default.
• W2042738496 hasRelatedWork W2010127283 @default.
• W2042738496 hasRelatedWork W2024197326 @default.
• W2042738496 hasRelatedWork W2053823780 @default.
• W2042738496 hasRelatedWork W2082257591 @default.
• W2042738496 hasRelatedWork W2790736181 @default.

• next