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• W2042742782 abstract "xol-1 is the earliest-acting gene in the known hierarchy that controls C. elegans sex determination and dosage compensation. We show that the primary sex-determining signal (the X/A ratio) directs the choice of sexual fate by regulating xol-1 transcript levels: high xol-1 expression during gastrulation triggers male development, whereas low expression at that time permits hermaphrodite development. Inappropriately high xol-1 expression causes hermaphrodites to activate the male program of development and die from a disruption in dosage compensation. These results demonstrate that xol-1 functions as an early developmental switch to set the choice of sexual fate and suggest that assessment of the X/A ratio occurs only early in embryogenesis to determine sex. Moreover, sdc-2, a gene that must be repressed by xol-1 to ensure male development, may be a direct target of negative regulation by xol-1." @default.
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• W2042742782 date "1995-01-01" @default.
• W2042742782 modified "2023-09-30" @default.
• W2042742782 title "xo1-1 acts as an early switch in the C. elegans male/hermaphrodite decision" @default.
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• W2042742782 doi "https://doi.org/10.1016/0092-8674(95)90452-2" @default.
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