FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042743827> ?p ?o ?g. }

• W2042743827 endingPage "2201" @default.
• W2042743827 startingPage "2193" @default.
• W2042743827 abstract "Abstract Nitric oxide (NO) has been implicated in many pathophysiological situations in the lung, including hypoxia/reoxygenation. This work seeks to clarify the current controversy concerning the double protective/toxic role of endogenous NO under hypoxia/reoxygenation situations in the lung by using a nitric oxide synthase (NOS) inhibitor, in a novel approach to address the problems raised from assaults under such circumstances. A follow‐up study was conducted in Wistar rats submitted to hypoxia/reoxygenation (hypoxia for 30 min; reoxygenation of 0 h, 48 h, and 5 days), with or without prior treatment using the nonselective NOS inhibitor L ‐NAME (1.5 mM, in drinking water). Lipid peroxidation, apoptosis level, protein nitration, in situ NOS activity and NO production (NOx) were analyzed. This is the first work to focus on the time‐course effects of L ‐NAME in the adult rat lung submitted to hypoxia/reoxygenation. The results showed that after L ‐NAME administration, in situ NOS activity was almost completely eliminated and consequently, NOx levels fell. Lipid peroxidation and the percentage of apoptotic cells rose at the earliest reoxygenation time (0 h), but decreased in the later period (48 h and 5 days). Also nitrated protein expression decreased at 48 h and 5 days posthypoxia. These results suggest that NOS‐derived NO exerts two different effects on lung hypoxia/reoxygenation injury depending on the reoxygenation time: NO has a beneficial role just after the hypoxic stimulus and a deleterious effect in the later reoxygenation times. Moreover, we propose that this dual role of NO depends directly on the producer NOS isoform. Anat Rec, 2010. © 2010 Wiley‐Liss, Inc." @default.
• W2042743827 created "2016-06-24" @default.
• W2042743827 creator A5020600950 @default.
• W2042743827 creator A5023463626 @default.
• W2042743827 creator A5051872536 @default.
• W2042743827 creator A5055947181 @default.
• W2042743827 date "2010-08-23" @default.
• W2042743827 modified "2023-10-17" @default.
• W2042743827 title "Endogenous Nitric Oxide Can Act as Beneficial or Deleterious in the Hypoxic Lung Depending on the Reoxygenation Time" @default.
• W2042743827 cites W107445082 @default.
• W2042743827 cites W1590457525 @default.
• W2042743827 cites W1972040145 @default.
• W2042743827 cites W1973262286 @default.
• W2042743827 cites W1980021607 @default.
• W2042743827 cites W1983039463 @default.
• W2042743827 cites W1993570261 @default.
• W2042743827 cites W2007737411 @default.
• W2042743827 cites W2008308749 @default.
• W2042743827 cites W2009677832 @default.
• W2042743827 cites W2011347602 @default.
• W2042743827 cites W2012326377 @default.
• W2042743827 cites W2023690476 @default.
• W2042743827 cites W2024417244 @default.
• W2042743827 cites W2027737927 @default.
• W2042743827 cites W2028123418 @default.
• W2042743827 cites W2041283753 @default.
• W2042743827 cites W2042943786 @default.
• W2042743827 cites W2053353899 @default.
• W2042743827 cites W2061092938 @default.
• W2042743827 cites W2064347448 @default.
• W2042743827 cites W2070165290 @default.
• W2042743827 cites W2074042972 @default.
• W2042743827 cites W2076347904 @default.
• W2042743827 cites W2077078803 @default.
• W2042743827 cites W2085115373 @default.
• W2042743827 cites W2085990440 @default.
• W2042743827 cites W2095991593 @default.
• W2042743827 cites W2098227404 @default.
• W2042743827 cites W2111718849 @default.
• W2042743827 cites W2118571380 @default.
• W2042743827 cites W2128733654 @default.
• W2042743827 cites W2146795759 @default.
• W2042743827 cites W2150785182 @default.
• W2042743827 cites W2157430977 @default.
• W2042743827 cites W2157679203 @default.
• W2042743827 cites W2169277949 @default.
• W2042743827 cites W2171919318 @default.
• W2042743827 cites W2407737746 @default.
• W2042743827 cites W4293247451 @default.
• W2042743827 doi "https://doi.org/10.1002/ar.21229" @default.
• W2042743827 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20734424" @default.
• W2042743827 hasPublicationYear "2010" @default.
• W2042743827 type Work @default.
• W2042743827 sameAs 2042743827 @default.
• W2042743827 citedByCount "7" @default.
• W2042743827 countsByYear W20427438272013 @default.
• W2042743827 countsByYear W20427438272014 @default.
• W2042743827 countsByYear W20427438272015 @default.
• W2042743827 countsByYear W20427438272019 @default.
• W2042743827 countsByYear W20427438272020 @default.
• W2042743827 crossrefType "journal-article" @default.
• W2042743827 hasAuthorship W2042743827A5020600950 @default.
• W2042743827 hasAuthorship W2042743827A5023463626 @default.
• W2042743827 hasAuthorship W2042743827A5051872536 @default.
• W2042743827 hasAuthorship W2042743827A5055947181 @default.
• W2042743827 hasBestOaLocation W20427438271 @default.
• W2042743827 hasConcept C126322002 @default.
• W2042743827 hasConcept C16613235 @default.
• W2042743827 hasConcept C178790620 @default.
• W2042743827 hasConcept C185592680 @default.
• W2042743827 hasConcept C190283241 @default.
• W2042743827 hasConcept C2776151105 @default.
• W2042743827 hasConcept C2777622882 @default.
• W2042743827 hasConcept C2777714996 @default.
• W2042743827 hasConcept C2780829032 @default.
• W2042743827 hasConcept C42219234 @default.
• W2042743827 hasConcept C519581460 @default.
• W2042743827 hasConcept C540031477 @default.
• W2042743827 hasConcept C55493867 @default.
• W2042743827 hasConcept C71924100 @default.
• W2042743827 hasConcept C7836513 @default.
• W2042743827 hasConcept C98274493 @default.
• W2042743827 hasConceptScore W2042743827C126322002 @default.
• W2042743827 hasConceptScore W2042743827C16613235 @default.
• W2042743827 hasConceptScore W2042743827C178790620 @default.
• W2042743827 hasConceptScore W2042743827C185592680 @default.
• W2042743827 hasConceptScore W2042743827C190283241 @default.
• W2042743827 hasConceptScore W2042743827C2776151105 @default.
• W2042743827 hasConceptScore W2042743827C2777622882 @default.
• W2042743827 hasConceptScore W2042743827C2777714996 @default.
• W2042743827 hasConceptScore W2042743827C2780829032 @default.
• W2042743827 hasConceptScore W2042743827C42219234 @default.
• W2042743827 hasConceptScore W2042743827C519581460 @default.
• W2042743827 hasConceptScore W2042743827C540031477 @default.
• W2042743827 hasConceptScore W2042743827C55493867 @default.
• W2042743827 hasConceptScore W2042743827C71924100 @default.
• W2042743827 hasConceptScore W2042743827C7836513 @default.
• W2042743827 hasConceptScore W2042743827C98274493 @default.

• next