Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042763614> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2042763614 endingPage "98" @default.
- W2042763614 startingPage "95" @default.
- W2042763614 abstract "Abstract. The antigonadotropic action of danazol is still a subject Of COntrOVerSy. Danazol does not cause a consistent and significant suppression of basal gonadotropin concentrations in premenopausal women. In order to investigate the possible effects of danazol on circulating gonadotropin levels in the absence of gonadal feedback, postmenopausal women were studied. Twelve healthy women, at least 3 Years Past the menoPau% volunteered. Their mean age was 61.1253 (SD) years. Danazol in daily doses of 400, 600 or 800 mg was given randomized, to 4 patients each, for 4 weeks. Venous samples were drawn at −1, 0, +1, + 2, +4 weeks of medication. FSH and LH in serum were measured by means of double antibody radio-immunoassay. There was no significant difference between any of the pre-treatment means in the three dose groups. After 4 weeks of danazol treatment, FSH had decreased by 18%, 31%. and 32% in the 400, 600 and 800 mg groups, respectively. The corresponding decreases in LH were 14%. 24% and 21%. There was no significant dose response between any of the doses used. In the absence of significant differences between the pretreatment means and of significant dose response, data for all 12 patients were pooled for statistical evaluation. The mean decrease in FSH was significant only after 4 weeks (−4.8 pg/l; p<0.001). The mean decrease in LH was significant after 1, 2 and 4 weeks of treatment (−1.0 to − 1.13; p<0.01 or less). The results support the view that the pharmacodynamic spectrum of actions of danazol, even in the absence of gonadal feedback, includes a direct effect on gonadotropin secretion at hypothalamic-pituitary level." @default.
- W2042763614 created "2016-06-24" @default.
- W2042763614 creator A5013473826 @default.
- W2042763614 creator A5059532015 @default.
- W2042763614 creator A5086108888 @default.
- W2042763614 date "1984-01-01" @default.
- W2042763614 modified "2023-10-16" @default.
- W2042763614 title "Effect of danazol on serum concentrations of pituitary gonadotropins in postmenopausal women" @default.
- W2042763614 cites W112482003 @default.
- W2042763614 cites W121911708 @default.
- W2042763614 cites W1993162450 @default.
- W2042763614 cites W2013625413 @default.
- W2042763614 cites W2135348351 @default.
- W2042763614 cites W2210149071 @default.
- W2042763614 cites W2278624344 @default.
- W2042763614 cites W2289511083 @default.
- W2042763614 cites W2308234464 @default.
- W2042763614 cites W2444536610 @default.
- W2042763614 cites W2460448269 @default.
- W2042763614 doi "https://doi.org/10.3109/00016348409156991" @default.
- W2042763614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6437128" @default.
- W2042763614 hasPublicationYear "1984" @default.
- W2042763614 type Work @default.
- W2042763614 sameAs 2042763614 @default.
- W2042763614 citedByCount "4" @default.
- W2042763614 crossrefType "journal-article" @default.
- W2042763614 hasAuthorship W2042763614A5013473826 @default.
- W2042763614 hasAuthorship W2042763614A5059532015 @default.
- W2042763614 hasAuthorship W2042763614A5086108888 @default.
- W2042763614 hasConcept C126322002 @default.
- W2042763614 hasConcept C134018914 @default.
- W2042763614 hasConcept C2777416354 @default.
- W2042763614 hasConcept C2778024521 @default.
- W2042763614 hasConcept C2778575703 @default.
- W2042763614 hasConcept C2778782382 @default.
- W2042763614 hasConcept C2779279165 @default.
- W2042763614 hasConcept C2779306644 @default.
- W2042763614 hasConcept C2779522080 @default.
- W2042763614 hasConcept C71315377 @default.
- W2042763614 hasConcept C71924100 @default.
- W2042763614 hasConceptScore W2042763614C126322002 @default.
- W2042763614 hasConceptScore W2042763614C134018914 @default.
- W2042763614 hasConceptScore W2042763614C2777416354 @default.
- W2042763614 hasConceptScore W2042763614C2778024521 @default.
- W2042763614 hasConceptScore W2042763614C2778575703 @default.
- W2042763614 hasConceptScore W2042763614C2778782382 @default.
- W2042763614 hasConceptScore W2042763614C2779279165 @default.
- W2042763614 hasConceptScore W2042763614C2779306644 @default.
- W2042763614 hasConceptScore W2042763614C2779522080 @default.
- W2042763614 hasConceptScore W2042763614C71315377 @default.
- W2042763614 hasConceptScore W2042763614C71924100 @default.
- W2042763614 hasIssue "s123" @default.
- W2042763614 hasLocation W20427636141 @default.
- W2042763614 hasLocation W20427636142 @default.
- W2042763614 hasOpenAccess W2042763614 @default.
- W2042763614 hasPrimaryLocation W20427636141 @default.
- W2042763614 hasRelatedWork W2045160985 @default.
- W2042763614 hasRelatedWork W2058133591 @default.
- W2042763614 hasRelatedWork W2060776757 @default.
- W2042763614 hasRelatedWork W2079716555 @default.
- W2042763614 hasRelatedWork W2119310050 @default.
- W2042763614 hasRelatedWork W2133240828 @default.
- W2042763614 hasRelatedWork W2134449442 @default.
- W2042763614 hasRelatedWork W2137815118 @default.
- W2042763614 hasRelatedWork W2150623837 @default.
- W2042763614 hasRelatedWork W2411332413 @default.
- W2042763614 hasVolume "63" @default.
- W2042763614 isParatext "false" @default.
- W2042763614 isRetracted "false" @default.
- W2042763614 magId "2042763614" @default.
- W2042763614 workType "article" @default.