FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042763886> ?p ?o ?g. }

• W2042763886 endingPage "473" @default.
• W2042763886 startingPage "467" @default.
• W2042763886 abstract "A biologically active spin-labeled derivative of amphotericin B has been synthesized by the nucleophilic addition of amphotericin B to 4-(2-iodoacetamido)-2,2',6,6'-tetramethylpiperadine-N-oxyl in dimethyl-sulphoxide at 40 degrees C. The derivative is a moderately water-soluble compound which displays the same biological activity of the parental compound against the sensitive organism Leishmania mexicana; also, the rates of proton-cation exchange induced by the two compounds in large unilamellar liposomes are indistinguishable. The ESR spectra of spin-labeled amphotericin B in lipid vesicles indicate a high degree of motion, very similar to that encountered for the compound in aqueous solutions at neutral pH and in deoxycholate micelles, and suggest that the structures formed by the antibiotic in membranes are composed by a small number of molecules. In contrast, the spectra of the labeled antibiotic in ethanol, diethyl ether and dimethylformamide indicate restricted motion and exchange interactions, probably resulting from the micellar aggregation induced in these media. Ascorbate at 10 mM is able to reduce completely the nitroxide group of the labeled antibiotic in lipid vesicles in less than 30 s, indicating that an asymmetric disposition of the antibiotic molecules across the membrane is capable of inducing its biological and ionophoric properties. Ni2+ and Cu2+ produce moderate exchange broadening of the ESR signal of spin-labeled amphotericin B in lipid vesicles; the comparison of this phenomenom with the exchange broadening produced by the same ions in the ESR spectrum of 2,2',6,6'-tetramethylpiperidine-N-oxyl in water solution suggests an specific Cu2+-amphotericin B interaction in membranes." @default.
• W2042763886 created "2016-06-24" @default.
• W2042763886 creator A5002541919 @default.
• W2042763886 creator A5014684114 @default.
• W2042763886 creator A5037256279 @default.
• W2042763886 creator A5091645168 @default.
• W2042763886 date "1987-03-01" @default.
• W2042763886 modified "2023-09-26" @default.
• W2042763886 title "Spin-labeled amphotericin B: synthesis, characterization, biological and spectroscopic properties" @default.
• W2042763886 cites W1262927677 @default.
• W2042763886 cites W1533842075 @default.
• W2042763886 cites W1964963387 @default.
• W2042763886 cites W1973732405 @default.
• W2042763886 cites W1981796897 @default.
• W2042763886 cites W1982525306 @default.
• W2042763886 cites W1985522113 @default.
• W2042763886 cites W1988722254 @default.
• W2042763886 cites W1996782755 @default.
• W2042763886 cites W2004690064 @default.
• W2042763886 cites W2006509814 @default.
• W2042763886 cites W2013892132 @default.
• W2042763886 cites W2017616127 @default.
• W2042763886 cites W2018305634 @default.
• W2042763886 cites W2021234433 @default.
• W2042763886 cites W2021680270 @default.
• W2042763886 cites W2023788551 @default.
• W2042763886 cites W2028029370 @default.
• W2042763886 cites W2036385074 @default.
• W2042763886 cites W2037587995 @default.
• W2042763886 cites W2040733820 @default.
• W2042763886 cites W2050766948 @default.
• W2042763886 cites W2059211918 @default.
• W2042763886 cites W2061858476 @default.
• W2042763886 cites W2065522184 @default.
• W2042763886 cites W2088889347 @default.
• W2042763886 cites W2089707772 @default.
• W2042763886 cites W2091084349 @default.
• W2042763886 cites W2094245441 @default.
• W2042763886 cites W2094355878 @default.
• W2042763886 cites W2101603966 @default.
• W2042763886 cites W2118372421 @default.
• W2042763886 cites W2119950290 @default.
• W2042763886 cites W2137502772 @default.
• W2042763886 cites W256192092 @default.
• W2042763886 cites W2743792571 @default.
• W2042763886 cites W4249583259 @default.
• W2042763886 cites W4317676090 @default.
• W2042763886 doi "https://doi.org/10.1016/0005-2736(87)90443-3" @default.
• W2042763886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3028486" @default.
• W2042763886 hasPublicationYear "1987" @default.
• W2042763886 type Work @default.
• W2042763886 sameAs 2042763886 @default.
• W2042763886 citedByCount "19" @default.
• W2042763886 countsByYear W20427638862012 @default.
• W2042763886 countsByYear W20427638862014 @default.
• W2042763886 countsByYear W20427638862015 @default.
• W2042763886 countsByYear W20427638862017 @default.
• W2042763886 countsByYear W20427638862018 @default.
• W2042763886 countsByYear W20427638862019 @default.
• W2042763886 crossrefType "journal-article" @default.
• W2042763886 hasAuthorship W2042763886A5002541919 @default.
• W2042763886 hasAuthorship W2042763886A5014684114 @default.
• W2042763886 hasAuthorship W2042763886A5037256279 @default.
• W2042763886 hasAuthorship W2042763886A5091645168 @default.
• W2042763886 hasConcept C116073593 @default.
• W2042763886 hasConcept C125501631 @default.
• W2042763886 hasConcept C130316041 @default.
• W2042763886 hasConcept C16005928 @default.
• W2042763886 hasConcept C178790620 @default.
• W2042763886 hasConcept C184651966 @default.
• W2042763886 hasConcept C185154212 @default.
• W2042763886 hasConcept C185592680 @default.
• W2042763886 hasConcept C202751555 @default.
• W2042763886 hasConcept C2777712214 @default.
• W2042763886 hasConcept C2779548794 @default.
• W2042763886 hasConcept C2779629538 @default.
• W2042763886 hasConcept C2780471494 @default.
• W2042763886 hasConcept C32909587 @default.
• W2042763886 hasConcept C41625074 @default.
• W2042763886 hasConcept C55493867 @default.
• W2042763886 hasConcept C71240020 @default.
• W2042763886 hasConcept C71924100 @default.
• W2042763886 hasConceptScore W2042763886C116073593 @default.
• W2042763886 hasConceptScore W2042763886C125501631 @default.
• W2042763886 hasConceptScore W2042763886C130316041 @default.
• W2042763886 hasConceptScore W2042763886C16005928 @default.
• W2042763886 hasConceptScore W2042763886C178790620 @default.
• W2042763886 hasConceptScore W2042763886C184651966 @default.
• W2042763886 hasConceptScore W2042763886C185154212 @default.
• W2042763886 hasConceptScore W2042763886C185592680 @default.
• W2042763886 hasConceptScore W2042763886C202751555 @default.
• W2042763886 hasConceptScore W2042763886C2777712214 @default.
• W2042763886 hasConceptScore W2042763886C2779548794 @default.
• W2042763886 hasConceptScore W2042763886C2779629538 @default.
• W2042763886 hasConceptScore W2042763886C2780471494 @default.
• W2042763886 hasConceptScore W2042763886C32909587 @default.
• W2042763886 hasConceptScore W2042763886C41625074 @default.
• W2042763886 hasConceptScore W2042763886C55493867 @default.

• next