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• W2042771330 abstract "X chromosome inactivation is the mammalian answer to the dilemma of dosage compensation between males and females. The study of this fascinating form of chromosome-wide gene regulation has yielded surprising insights into early development and cellular memory. In the past few months, three papers1-3 reported unexpected findings about the paternal X chromosome (Xp). All three studies agree that the Xp is imprinted to become inactive earlier than ever suspected during embryonic development. Although apparently incomplete, this early form of inactivation insures dosage compensation throughout development. Silencing of the Xp persists in cells of extraembryonic tissues, but it is erased and followed by random X inactivation in cells of the embryo proper. These findings challenge several aspects of the current view of X inactivation during early development and may have profound impact on studies of pluripotency and epigenetics. BioEssays 26:821–824, 2004. © 2004 Wiley Periodicals, Inc." @default.
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• W2042771330 date "2004-01-01" @default.
• W2042771330 modified "2023-10-01" @default.
• W2042771330 title "Silence of the fathers: Early X inactivation" @default.
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• W2042771330 doi "https://doi.org/10.1002/bies.20082" @default.
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