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• W2042772337 abstract "Demonstrating the importance of the gut microbiota in human health and well-being represents a major transformational task in both medical and nutritional research. Owing to the high-throughput -omics methodologies, the complexity, evolution with age, and individual nature of the gut microflora have been more thoroughly investigated. The balance between this complex community of gut bacteria, food nutrients, and intestinal genomic and physiological milieu is increasingly recognized as a major contributor to human health and disease. This article discusses the “gutome,” that is, nutritional systems biology of gut microbiome and host–microbiome interactions. We examine the novel ways in which the study of the human gutome, and nutrigenomics more generally, can have translational and transformational impacts in 21st century practice of biomedicine. We describe the clinical context in which experimental methodologies, as well as data-driven and process-driven approaches are being utilized in nutrigenomics and microbiome research. We underscore the pivotal importance of the gutome as a common platform for sharing data in the emerging field of the integrated metagenomics of gut pathophysiology. This vision needs to be articulated in a manner that recognizes both the omics biotechnology nuances and the ways in which nutrigenomics science can effectively inform population health and public policy, and vice versa." @default.
• W2042772337 created "2016-06-24" @default.
• W2042772337 creator A5037557782 @default.
• W2042772337 date "2011-07-01" @default.
• W2042772337 modified "2023-10-12" @default.
• W2042772337 title "The Human Gutome: Nutrigenomics of the Host–Microbiome Interactions" @default.
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• W2042772337 doi "https://doi.org/10.1089/omi.2010.0109" @default.
• W2042772337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21121704" @default.
• W2042772337 hasPublicationYear "2011" @default.
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