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- W2042777304 abstract "It has been reported in the earlier literature that many patients with psychoses had abnormalities in glucose metabolism as revealed by glucose tolerance testing. This observation is reinforced by the fact that the schizophrenic population appears to have about a 2-3-fold increased risk for Type II diabetes mellitus. However, some uncertainty remains about the relative risk value because there have been numerous case reports of patients who developed hyperglycemia and even Type II diabetes apparently as a consequence of treatment with antipsychotic drugs. Schizophrenic patients with abnormal glucose metabolism have a higher prevalence of drug-induced tardive dyskinesia than patients with a normal glucose profile. Treatment with the new atypical antipsychotics has a much lower risk of movement disorders; however, weight gain, hyperglycemia, and diabetes are emerging as significant side effects. Because glucose is essential for energy metabolism in neurons, any change in the effective glucose levels in brain that result from drug therapy may have significant clinical implications. It is not clear whether the glycemic state of schizophrenics contributes to their psychotic symptoms or modulates the incidence of drug side effects. Basic research shows that the drugs which cause hyperglycemia in patients appear to inhibit neuronal glucose transport which may partly explain their effects. This paper reviews the relevant literature in a preliminary attempt to understand the implications of such clinical findings in the light of basic research." @default.
- W2042777304 created "2016-06-24" @default.
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- W2042777304 date "2001-01-01" @default.
- W2042777304 modified "2023-09-27" @default.
- W2042777304 cites W1480115800 @default.
- W2042777304 cites W1497918213 @default.
- W2042777304 cites W184628882 @default.
- W2042777304 cites W1958855959 @default.
- W2042777304 cites W1963840316 @default.
- W2042777304 cites W1964350249 @default.
- W2042777304 cites W1968674945 @default.
- W2042777304 cites W1969014257 @default.
- W2042777304 cites W1969707286 @default.
- W2042777304 cites W1972023245 @default.
- W2042777304 cites W1972575403 @default.
- W2042777304 cites W1972723341 @default.
- W2042777304 cites W1973802181 @default.
- W2042777304 cites W1974843265 @default.
- W2042777304 cites W1976368638 @default.
- W2042777304 cites W1982157077 @default.
- W2042777304 cites W1987850725 @default.
- W2042777304 cites W1990561545 @default.
- W2042777304 cites W1990789722 @default.
- W2042777304 cites W1990821692 @default.
- W2042777304 cites W1994182801 @default.
- W2042777304 cites W1998638899 @default.
- W2042777304 cites W2001701208 @default.
- W2042777304 cites W2004644712 @default.
- W2042777304 cites W2009070544 @default.
- W2042777304 cites W2009653276 @default.
- W2042777304 cites W2010762931 @default.
- W2042777304 cites W2011614524 @default.
- W2042777304 cites W2012424893 @default.
- W2042777304 cites W2019115177 @default.
- W2042777304 cites W2020676501 @default.
- W2042777304 cites W2026291106 @default.
- W2042777304 cites W2026473642 @default.
- W2042777304 cites W2029952781 @default.
- W2042777304 cites W2031204779 @default.
- W2042777304 cites W2035155106 @default.
- W2042777304 cites W2035924985 @default.
- W2042777304 cites W2036195993 @default.
- W2042777304 cites W2038500073 @default.
- W2042777304 cites W2039221880 @default.
- W2042777304 cites W2039239004 @default.
- W2042777304 cites W2041448996 @default.
- W2042777304 cites W2043160361 @default.
- W2042777304 cites W2044412220 @default.
- W2042777304 cites W2044425791 @default.
- W2042777304 cites W2044926400 @default.
- W2042777304 cites W2049119531 @default.
- W2042777304 cites W2050497940 @default.
- W2042777304 cites W2050623007 @default.
- W2042777304 cites W2055393039 @default.
- W2042777304 cites W2056742690 @default.
- W2042777304 cites W2059424172 @default.
- W2042777304 cites W2059479598 @default.
- W2042777304 cites W2060471046 @default.
- W2042777304 cites W2061519105 @default.
- W2042777304 cites W2062171893 @default.
- W2042777304 cites W2064052521 @default.
- W2042777304 cites W2065492458 @default.
- W2042777304 cites W2065520091 @default.
- W2042777304 cites W2072441600 @default.
- W2042777304 cites W2074833984 @default.
- W2042777304 cites W2077364398 @default.
- W2042777304 cites W2077935911 @default.
- W2042777304 cites W2078438409 @default.
- W2042777304 cites W2080564246 @default.
- W2042777304 cites W2081584258 @default.
- W2042777304 cites W2087866447 @default.
- W2042777304 cites W2089671853 @default.
- W2042777304 cites W2089775871 @default.
- W2042777304 cites W2092785858 @default.
- W2042777304 cites W2093714281 @default.
- W2042777304 cites W2095864523 @default.
- W2042777304 cites W2104773633 @default.
- W2042777304 cites W2106969054 @default.
- W2042777304 cites W2107153071 @default.
- W2042777304 cites W2111105929 @default.
- W2042777304 cites W2121713405 @default.
- W2042777304 cites W2123031556 @default.
- W2042777304 cites W2123102900 @default.
- W2042777304 cites W2125207055 @default.
- W2042777304 cites W2127081103 @default.
- W2042777304 cites W2132335976 @default.
- W2042777304 cites W2136433521 @default.
- W2042777304 cites W2137019832 @default.
- W2042777304 cites W2139285806 @default.
- W2042777304 cites W2140251161 @default.
- W2042777304 cites W2147949752 @default.
- W2042777304 cites W2150311857 @default.
- W2042777304 cites W2159742364 @default.
- W2042777304 cites W2169194266 @default.
- W2042777304 cites W2170498560 @default.
- W2042777304 cites W2171854040 @default.