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- W2042796334 abstract "Two diarylheptanoids, oregonin (1) and hirsutanone (2), were isolated by bioassay-guided fractionation of the methanol extracts of the leaves of Alnus japonica Steud and their structures were elucidated from their spectroscopic data. Compounds 1 and 2 exhibited significant low-density lipoprotein (LDL)-antioxidant activities, e. g., thiobarbituric acid-reactive substances (TBARS) assay (1: IC50 = 3.2 microM, 2: IC50 = 1.5 microM), lag time (1 : 162 min, 2 : 230 min at 2.0 microM, control: 63 min), relative electrophoretic mobility (REM, inhibition of 1 : 71%, 2 : 75% at 10 microM), apoB-100 fragmentation (inhibition of 1 : 27.3%, 2 : 40.3% at 10 microM) and macrophage-mediated LDL oxidation (inhibition of 1 : 82%, 2 : 84% at 1 microM)." @default.
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- W2042796334 date "2005-04-01" @default.
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- W2042796334 title "Antioxidant Effects of Diarylheptanoid Derivatives from<i>Alnus japonica</i>on Human LDL Oxidation" @default.
- W2042796334 doi "https://doi.org/10.1055/s-2005-864093" @default.
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