FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042800972> ?p ?o ?g. }

• W2042800972 endingPage "196" @default.
• W2042800972 startingPage "186" @default.
• W2042800972 abstract "The antioxidant tripeptide glutathione (GSH) protects ovarian follicles against oxidative damage that may lead to apoptotic death. The rate-limiting step in synthesis of GSH is catalyzed by glutamate cysteine ligase (GCL), a heterodimer composed of a catalytic subunit (GCLC), and a modifier subunit (GCLM). We hypothesized that GSH depletion in vivo or in vitro with buthionine sulfoximine (BSO), a specific inhibitor of GCL activity, would increase ovarian and granulosa cell GCL subunit expression. Ovarian glutathione levels are lowest on proestrous morning and increase to their highest levels on estrus and metestrus. Therefore, we treated rats on proestrous morning or on proestrous morning and again 12h later to prevent the normal increase in ovarian glutathione between proestrus and estrus. Ovarian Gclc and Gclm mRNA levels and GCLC protein levels increased transiently by 1.4-1.5-fold at 8 h, but not at 12 or 24 h, after a single dose of BSO administered to adult rats on the morning of proestrus. GCLC protein levels were also modestly increased 1.4-fold at 12 h after a second dose of BSO. GCLM protein levels increased 1.4-fold at 24 h after a single dose of BSO, but not at other time points. BSO treatment did not significantly alter ovarian GCL enzymatic activity or the intraovarian localization of either GCL subunit mRNA. Treatment of a human granulosa cell line or primary rat granulosa cells with BSO suppressed intracellular GSH; however, there was no compensatory upregulation of GCL subunit protein or mRNA levels. These results demonstrate that ovarian follicles and granulosa cells are minimally able to respond to acute GSH depletion by upregulating expression of GCL." @default.
• W2042800972 created "2016-06-24" @default.
• W2042800972 creator A5035985218 @default.
• W2042800972 creator A5036884005 @default.
• W2042800972 creator A5039209354 @default.
• W2042800972 date "2006-02-01" @default.
• W2042800972 modified "2023-09-25" @default.
• W2042800972 title "Minimal ovarian upregulation of glutamate cysteine ligase expression in response to suppression of glutathione by buthionine sulfoximine" @default.
• W2042800972 cites W1505246749 @default.
• W2042800972 cites W1538128477 @default.
• W2042800972 cites W1588826234 @default.
• W2042800972 cites W1898716493 @default.
• W2042800972 cites W1968673718 @default.
• W2042800972 cites W1974690510 @default.
• W2042800972 cites W1977355382 @default.
• W2042800972 cites W1982585224 @default.
• W2042800972 cites W1989953524 @default.
• W2042800972 cites W1992298777 @default.
• W2042800972 cites W2001447031 @default.
• W2042800972 cites W2003706186 @default.
• W2042800972 cites W2010584942 @default.
• W2042800972 cites W2010939021 @default.
• W2042800972 cites W2028484565 @default.
• W2042800972 cites W2029490482 @default.
• W2042800972 cites W2033258594 @default.
• W2042800972 cites W2036571368 @default.
• W2042800972 cites W2055419513 @default.
• W2042800972 cites W2082438874 @default.
• W2042800972 cites W2084962835 @default.
• W2042800972 cites W2086971328 @default.
• W2042800972 cites W2092195942 @default.
• W2042800972 cites W2093016551 @default.
• W2042800972 cites W2094249744 @default.
• W2042800972 cites W2096043276 @default.
• W2042800972 cites W2105162966 @default.
• W2042800972 cites W2113883602 @default.
• W2042800972 cites W2138165502 @default.
• W2042800972 cites W2139084881 @default.
• W2042800972 cites W2290658472 @default.
• W2042800972 cites W2333999289 @default.
• W2042800972 cites W2338598306 @default.
• W2042800972 cites W2950358277 @default.
• W2042800972 cites W4238948349 @default.
• W2042800972 cites W4240440085 @default.
• W2042800972 cites W50357670 @default.
• W2042800972 doi "https://doi.org/10.1016/j.reprotox.2005.07.011" @default.
• W2042800972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16183247" @default.
• W2042800972 hasPublicationYear "2006" @default.
• W2042800972 type Work @default.
• W2042800972 sameAs 2042800972 @default.
• W2042800972 citedByCount "7" @default.
• W2042800972 countsByYear W20428009722012 @default.
• W2042800972 countsByYear W20428009722013 @default.
• W2042800972 countsByYear W20428009722014 @default.
• W2042800972 countsByYear W20428009722019 @default.
• W2042800972 countsByYear W20428009722021 @default.
• W2042800972 countsByYear W20428009722022 @default.
• W2042800972 crossrefType "journal-article" @default.
• W2042800972 hasAuthorship W2042800972A5035985218 @default.
• W2042800972 hasAuthorship W2042800972A5036884005 @default.
• W2042800972 hasAuthorship W2042800972A5039209354 @default.
• W2042800972 hasBestOaLocation W20428009722 @default.
• W2042800972 hasConcept C104317684 @default.
• W2042800972 hasConcept C126322002 @default.
• W2042800972 hasConcept C127561419 @default.
• W2042800972 hasConcept C134018914 @default.
• W2042800972 hasConcept C181199279 @default.
• W2042800972 hasConcept C1998276 @default.
• W2042800972 hasConcept C2777476445 @default.
• W2042800972 hasConcept C2779881523 @default.
• W2042800972 hasConcept C2781173740 @default.
• W2042800972 hasConcept C538909803 @default.
• W2042800972 hasConcept C55493867 @default.
• W2042800972 hasConcept C71924100 @default.
• W2042800972 hasConcept C86803240 @default.
• W2042800972 hasConceptScore W2042800972C104317684 @default.
• W2042800972 hasConceptScore W2042800972C126322002 @default.
• W2042800972 hasConceptScore W2042800972C127561419 @default.
• W2042800972 hasConceptScore W2042800972C134018914 @default.
• W2042800972 hasConceptScore W2042800972C181199279 @default.
• W2042800972 hasConceptScore W2042800972C1998276 @default.
• W2042800972 hasConceptScore W2042800972C2777476445 @default.
• W2042800972 hasConceptScore W2042800972C2779881523 @default.
• W2042800972 hasConceptScore W2042800972C2781173740 @default.
• W2042800972 hasConceptScore W2042800972C538909803 @default.
• W2042800972 hasConceptScore W2042800972C55493867 @default.
• W2042800972 hasConceptScore W2042800972C71924100 @default.
• W2042800972 hasConceptScore W2042800972C86803240 @default.
• W2042800972 hasIssue "2" @default.
• W2042800972 hasLocation W20428009721 @default.
• W2042800972 hasLocation W20428009722 @default.
• W2042800972 hasLocation W20428009723 @default.
• W2042800972 hasOpenAccess W2042800972 @default.
• W2042800972 hasPrimaryLocation W20428009721 @default.
• W2042800972 hasRelatedWork W1602004016 @default.
• W2042800972 hasRelatedWork W2014355861 @default.
• W2042800972 hasRelatedWork W2028766244 @default.
• W2042800972 hasRelatedWork W2042800972 @default.

• next