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- W2042803323 abstract "Summary. The inhibitory effect of (+)-, (−)-, (±)-gossypol and (±)-gossypol acetic acid upon testicular cytosolic LDH-X was measured in vitro. Gossypol acetic acid (0-100 μmol/l) inhibited LDH-X prepared from the testes of the mouse > rabbit > human > rat > hamster. There was no relationship between inhibition and in-vivo antifertility activity. LDH activity measured in vitro in serum of men and hamsters was unaffected by gossypol. Gossypol and its isomers were non-competitive inhibitors of human and hamster LDH-X with respect to the coenzyme NADH, competitive inhibitors of human LDH-X and noncompetitive—competitive inhibitors of hamster LDH-X with respect to the substrate α-ketobutyrate. Co-incubation with human serum albumin or poly-l-lysine but not lysine protected human and hamster LDH-X from gossypol." @default.
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- W2042803323 date "1986-07-01" @default.
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- W2042803323 title "Inhibition of testicular LDH-X from laboratory animals and man by gossypol and its isomers" @default.
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- W2042803323 doi "https://doi.org/10.1530/jrf.0.0770607" @default.
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