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- W2042804250 abstract "Among pathogenic Enterobacteriaceae, the proteins of the Ail/OmpX/PagC family form a steadily growing family of outer membrane proteins with diverse biological properties, potentially involved in virulence such as human serum resistance, adhesion and entry into eukaryotic culture cells. We studied the proteins Ail/OmpX/PagC in the bacterial Photorhabdus genus. The Photorhabdus bacteria form symbiotic complexes with nematodes of Heterorhabditis species, associations which are pathogenic to insect larvae. Our phylogenetic analysis indicated that in Photorhabdus asymbiotica and Photorhabdus luminescens only Ail and PagC proteins are encoded. The genomic analysis revealed that the Photorhabdus ail and pagC genes were present in a unique copy, except two ail paralogs from P. luminescens. These genes, referred to as ail1Pl and ail2Pl, probably resulted from a recent tandem duplication. Surprisingly, only ail1Pl expression was directly controlled by PhoPQ and low external Mg2+ conditions. In P. luminescens, the magnesium-sensing two-component regulatory system PhoPQ regulates the outer membrane barrier and is required for pathogenicity against insects. In order to characterize Ail functions in Photorhabdus, we showed that only ail2Pl and pagCPl had the ability, when expressed into Escherichia coli, to confer resistance to complement in human serum. However no effect in resistance to antimicrobial peptides was found. Thus, the role of Ail and PagC proteins in Photorhabdus life cycle is discussed." @default.
- W2042804250 created "2016-06-24" @default.
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- W2042804250 date "2014-10-15" @default.
- W2042804250 modified "2023-10-18" @default.
- W2042804250 title "Ail and PagC-Related Proteins in the Entomopathogenic Bacteria of Photorhabdus Genus" @default.
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- W2042804250 doi "https://doi.org/10.1371/journal.pone.0110060" @default.
- W2042804250 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4198210" @default.
- W2042804250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25333642" @default.
- W2042804250 hasPublicationYear "2014" @default.
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