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• W2042809657 abstract "Attachments of dorsal root ganglion (DRG) neurons from streptozotocin (STZ)-induced diabetic and normal C57SL mice to the following substrates were evaluated in vitro: a) poly L-lysine (PL), b) PL + type I collagen (CL-q, c) PL + type IV collagen (CL-M, d) PL + laminin (LM) and e) PL + fibronectin (FN). After 8 h in culture, there was no significant difference in the average ratio of cells adhesive to PL between the diabetic (74.9 %) and normal group of mice (75.8%). In the normal group, the addition of extracellular matrix (ECM) proteins such as CL-I, CLIV, LM and FN to PL increased the ratios of cell attachment from 75.8% to nearly 90%. In the diabetic group, however, none of these proteins Improved the attachment (the ratio changed from 74.9% to nearly 70%). Survival and neurite extension of attached cells after 48 h in culture were not different between the two groups. These results suggest that the cell-surface receptors, which enable DRG neurons to bind to the extracellular matrix proteins, are Impaired by diabetes, resulting in being one of the causes of diabetic neuropathy." @default.
• W2042809657 created "2016-06-24" @default.
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• W2042809657 date "1995-01-01" @default.
• W2042809657 modified "2023-10-14" @default.
• W2042809657 title "Diabetes impairs DRG neuronal attachment to extracellular matrix proteins in vitro" @default.
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• W2042809657 doi "https://doi.org/10.1016/0361-9230(95)00057-l" @default.
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