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- W2042816528 abstract "WASP family proteins are involved in cortical actin cytoskeleton reorganization. Neural Wiskott–Aldrich syndrome protein (N-WASP), a ubiquitously expressed WASP homologous protein, directly binds with Cdc42, activating Arp2/3 complex. In this study, we show that N-WASP-dependent microspike formation is inhibited by formin binding protein 11 (FBP11). Endogenous FBP11 localizes with nuclear-speckles, and co-localization of N-WASP and FBP11 was observed when they were co-expressed. Epidermal growth factor (EGF) induced actin-microspike formation in COS7 cells. However, transient expression of FBP11 suppressed N-WASP-dependent actin-microspike formation by trapping N-WASP in the nucleus. These results indicate that FBP11 regulates localization of N-WASP, thus negatively regulating the function of N-WASP in the cytoplasm." @default.
- W2042816528 created "2016-06-24" @default.
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- W2042816528 date "2004-01-01" @default.
- W2042816528 modified "2023-10-01" @default.
- W2042816528 title "FBP11 regulates nuclear localization of N-WASP and inhibits N-WASP-dependent microspike formation" @default.
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- W2042816528 doi "https://doi.org/10.1016/j.bbrc.2003.11.139" @default.
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