Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042836637> ?p ?o ?g. }
- W2042836637 endingPage "e46725" @default.
- W2042836637 startingPage "e46725" @default.
- W2042836637 abstract "The SH2-domain-containing leukocyte protein of 76 kDa (SLP-76) plays a critical scaffolding role in T cell receptor (TCR) signaling. As an adaptor protein that contains multiple protein-binding domains, SLP-76 interacts with many signaling molecules and links proximal receptor stimulation to downstream effectors. The function of SLP-76 in TCR signaling has been widely studied using the Jurkat human leukaemic T cell line through protein disruption or site-directed mutagenesis. However, a wide-scale characterization of SLP-76-dependant phosphorylation events is still lacking. Quantitative profiling of over a hundred tyrosine phosphorylation sites revealed new modes of regulation of phosphorylation of PAG, PI3K, and WASP while reconfirming previously established regulation of Itk, PLCγ, and Erk phosphorylation by SLP-76. The absence of SLP-76 also perturbed the phosphorylation of Src family kinases (SFKs) Lck and Fyn, and subsequently a large number of SFK-regulated signaling molecules. Altogether our data suggests unique modes of regulation of positive and negative feedback pathways in T cells by SLP-76, reconfirming its central role in the pathway." @default.
- W2042836637 created "2016-06-24" @default.
- W2042836637 creator A5000747236 @default.
- W2042836637 creator A5025899028 @default.
- W2042836637 creator A5032932763 @default.
- W2042836637 creator A5052972032 @default.
- W2042836637 creator A5087447670 @default.
- W2042836637 creator A5087718701 @default.
- W2042836637 creator A5089064917 @default.
- W2042836637 date "2012-10-11" @default.
- W2042836637 modified "2023-10-16" @default.
- W2042836637 title "Quantitative Phosphoproteomics Reveals SLP-76 Dependent Regulation of PAG and Src Family Kinases in T Cells" @default.
- W2042836637 cites W1484096248 @default.
- W2042836637 cites W1488213105 @default.
- W2042836637 cites W1489480230 @default.
- W2042836637 cites W1530890173 @default.
- W2042836637 cites W1572891678 @default.
- W2042836637 cites W1576212058 @default.
- W2042836637 cites W1582379379 @default.
- W2042836637 cites W1739820884 @default.
- W2042836637 cites W1854103749 @default.
- W2042836637 cites W1871691509 @default.
- W2042836637 cites W1964895626 @default.
- W2042836637 cites W1971692004 @default.
- W2042836637 cites W1971946737 @default.
- W2042836637 cites W1974561108 @default.
- W2042836637 cites W1977575313 @default.
- W2042836637 cites W1978359047 @default.
- W2042836637 cites W1978531552 @default.
- W2042836637 cites W1979769420 @default.
- W2042836637 cites W1981180578 @default.
- W2042836637 cites W1981245526 @default.
- W2042836637 cites W1981593008 @default.
- W2042836637 cites W1984726722 @default.
- W2042836637 cites W1984871500 @default.
- W2042836637 cites W1989987282 @default.
- W2042836637 cites W1993450321 @default.
- W2042836637 cites W1996549172 @default.
- W2042836637 cites W1997966956 @default.
- W2042836637 cites W2002943653 @default.
- W2042836637 cites W2007920860 @default.
- W2042836637 cites W2010435020 @default.
- W2042836637 cites W2013592169 @default.
- W2042836637 cites W2014177218 @default.
- W2042836637 cites W2015542496 @default.
- W2042836637 cites W2018344755 @default.
- W2042836637 cites W2023276714 @default.
- W2042836637 cites W2027090942 @default.
- W2042836637 cites W2027791850 @default.
- W2042836637 cites W2030086470 @default.
- W2042836637 cites W2030254950 @default.
- W2042836637 cites W2034161979 @default.
- W2042836637 cites W2043363499 @default.
- W2042836637 cites W2043820795 @default.
- W2042836637 cites W2046901206 @default.
- W2042836637 cites W2051810870 @default.
- W2042836637 cites W2051893022 @default.
- W2042836637 cites W2061900998 @default.
- W2042836637 cites W2063586295 @default.
- W2042836637 cites W2066039346 @default.
- W2042836637 cites W2071776905 @default.
- W2042836637 cites W2077229146 @default.
- W2042836637 cites W2077648546 @default.
- W2042836637 cites W2081613818 @default.
- W2042836637 cites W2087159097 @default.
- W2042836637 cites W2088315522 @default.
- W2042836637 cites W2094416835 @default.
- W2042836637 cites W2095103973 @default.
- W2042836637 cites W2096057003 @default.
- W2042836637 cites W2102931781 @default.
- W2042836637 cites W2103967533 @default.
- W2042836637 cites W2105381419 @default.
- W2042836637 cites W2110464252 @default.
- W2042836637 cites W2111021441 @default.
- W2042836637 cites W2115344884 @default.
- W2042836637 cites W2116023341 @default.
- W2042836637 cites W2118738797 @default.
- W2042836637 cites W2119731343 @default.
- W2042836637 cites W2122506182 @default.
- W2042836637 cites W2123792762 @default.
- W2042836637 cites W2126910411 @default.
- W2042836637 cites W2129060370 @default.
- W2042836637 cites W2134855648 @default.
- W2042836637 cites W2139159445 @default.
- W2042836637 cites W2140592061 @default.
- W2042836637 cites W2142543015 @default.
- W2042836637 cites W2143285612 @default.
- W2042836637 cites W2143826978 @default.
- W2042836637 cites W2150282983 @default.
- W2042836637 cites W2151734135 @default.
- W2042836637 cites W2152498364 @default.
- W2042836637 cites W2160675888 @default.
- W2042836637 cites W2170119368 @default.
- W2042836637 cites W2171833656 @default.
- W2042836637 cites W2140949201 @default.
- W2042836637 doi "https://doi.org/10.1371/journal.pone.0046725" @default.
- W2042836637 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3469622" @default.
- W2042836637 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23071622" @default.