FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042848097> ?p ?o ?g. }

• W2042848097 endingPage "1907" @default.
• W2042848097 startingPage "1901" @default.
• W2042848097 abstract "Increasing the complexity of their models, p53s are stabilized either in order to function (wt p53) or due to the loss of function (mutant p53) with acquiring a mysterious prion-like ability to drive the normal p53 into the abnormal conformation to gain new functions. As already recognized, the loss of trans-activating function leads to a stabilization of mutant p53 because of the disappearance of the p53-inducible proteins, which otherwise directly (Mdm-2) or indirectly (p21) target p53 for degradation. Simplifying further, I will discuss that the loss of function results in a dominant-negative effect and gain-of-function (a dominant-positive effect). Thus, mutant p53 lacking trans-activation function nevertheless may retain the ability to repress transcription due to its competition with numerous transcription factors for their coactivators. When mutant p53 competes with wt p53, the inhibition of the wt p53-dependent transcription is perceived as a dominant-negative effect. Just like trans-repression, a dominant-negative effect requires an excess of p53 and, therefore, a 'dominant'-negative effect is not dominant. Furthermore, the stabilization of an endogenous mt p53 due to the loss of wt functions cannot occur in the presence of the wt p53 allele. Given the inability of mutant p53 to accumulate in the presence of wt p53, a dominant-negative effect does not naturally occur and, not surprisingly, heterozygous mt/wt cells are rare. The detection of a dominant-negative effect simply indicates that mutant p53 indeed has lost its function. Last, since mutant p53 loses some or most but not all activities and accumulates in the absence of wt allele, gain-of-function can be considered as an exaggeration of the remaining functions. Applications to cancer therapy are discussed. -Blagosklonny, M. V. p53 from complexity to simplicity: mutant p53 stabilization, gain-of-function, and dominant-negative effect." @default.
• W2042848097 created "2016-06-24" @default.
• W2042848097 creator A5045764409 @default.
• W2042848097 date "2000-10-01" @default.
• W2042848097 modified "2023-10-17" @default.
• W2042848097 title "p53 from complexity to simplicity: mutant p53 stabilization, gain‐of‐function, and dominant‐negative effect" @default.
• W2042848097 cites W1490290866 @default.
• W2042848097 cites W1502991557 @default.
• W2042848097 cites W1525669528 @default.
• W2042848097 cites W1544851750 @default.
• W2042848097 cites W1548972556 @default.
• W2042848097 cites W1565881767 @default.
• W2042848097 cites W1594943176 @default.
• W2042848097 cites W1863595524 @default.
• W2042848097 cites W1966305351 @default.
• W2042848097 cites W1967203013 @default.
• W2042848097 cites W1969044026 @default.
• W2042848097 cites W1972148644 @default.
• W2042848097 cites W1975113086 @default.
• W2042848097 cites W1975122645 @default.
• W2042848097 cites W1977012301 @default.
• W2042848097 cites W1978400153 @default.
• W2042848097 cites W1978518304 @default.
• W2042848097 cites W1980396417 @default.
• W2042848097 cites W1985840237 @default.
• W2042848097 cites W1985999867 @default.
• W2042848097 cites W1986179131 @default.
• W2042848097 cites W1989936068 @default.
• W2042848097 cites W1991494214 @default.
• W2042848097 cites W1995211857 @default.
• W2042848097 cites W2001258296 @default.
• W2042848097 cites W2002292653 @default.
• W2042848097 cites W2012732349 @default.
• W2042848097 cites W2013136213 @default.
• W2042848097 cites W2015134893 @default.
• W2042848097 cites W2015519364 @default.
• W2042848097 cites W2018385269 @default.
• W2042848097 cites W2018884388 @default.
• W2042848097 cites W2029529223 @default.
• W2042848097 cites W2043912950 @default.
• W2042848097 cites W2043964688 @default.
• W2042848097 cites W2045086385 @default.
• W2042848097 cites W2048997359 @default.
• W2042848097 cites W2056530510 @default.
• W2042848097 cites W2058769115 @default.
• W2042848097 cites W2060618478 @default.
• W2042848097 cites W2061025663 @default.
• W2042848097 cites W2068691401 @default.
• W2042848097 cites W2069412625 @default.
• W2042848097 cites W2071133966 @default.
• W2042848097 cites W2072319696 @default.
• W2042848097 cites W2074451679 @default.
• W2042848097 cites W2078003307 @default.
• W2042848097 cites W2080125477 @default.
• W2042848097 cites W2082979850 @default.
• W2042848097 cites W2084733813 @default.
• W2042848097 cites W2085195718 @default.
• W2042848097 cites W2101936797 @default.
• W2042848097 cites W2105896701 @default.
• W2042848097 cites W2113761414 @default.
• W2042848097 cites W2114980992 @default.
• W2042848097 cites W2124809046 @default.
• W2042848097 cites W2129030898 @default.
• W2042848097 cites W2132819345 @default.
• W2042848097 cites W2134388771 @default.
• W2042848097 cites W2143206501 @default.
• W2042848097 cites W2148119650 @default.
• W2042848097 cites W2149013144 @default.
• W2042848097 cites W2150710841 @default.
• W2042848097 cites W2151037269 @default.
• W2042848097 cites W2151085515 @default.
• W2042848097 cites W2152958744 @default.
• W2042848097 cites W2156299289 @default.
• W2042848097 cites W2158107656 @default.
• W2042848097 cites W2317236217 @default.
• W2042848097 cites W2324191190 @default.
• W2042848097 cites W2329020728 @default.
• W2042848097 cites W2330189712 @default.
• W2042848097 cites W2330704139 @default.
• W2042848097 cites W2334988436 @default.
• W2042848097 cites W2335302163 @default.
• W2042848097 doi "https://doi.org/10.1096/fj.99-1078rev" @default.
• W2042848097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11023974" @default.
• W2042848097 hasPublicationYear "2000" @default.
• W2042848097 type Work @default.
• W2042848097 sameAs 2042848097 @default.
• W2042848097 citedByCount "154" @default.
• W2042848097 countsByYear W20428480972012 @default.
• W2042848097 countsByYear W20428480972013 @default.
• W2042848097 countsByYear W20428480972014 @default.
• W2042848097 countsByYear W20428480972015 @default.
• W2042848097 countsByYear W20428480972016 @default.
• W2042848097 countsByYear W20428480972017 @default.
• W2042848097 countsByYear W20428480972018 @default.
• W2042848097 countsByYear W20428480972019 @default.
• W2042848097 countsByYear W20428480972020 @default.
• W2042848097 countsByYear W20428480972021 @default.
• W2042848097 countsByYear W20428480972022 @default.

• next