FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042851570> ?p ?o ?g. }

• W2042851570 endingPage "3189" @default.
• W2042851570 startingPage "3184" @default.
• W2042851570 abstract "GH replacement of adults with acquired GH deficiency (GHD) results in body composition changes including increases in lean mass and bone mineral density. However, the effects of long-term GH therapy on cognitive function are largely unknown, and there are conflicting data regarding quality of life. We performed a randomized, double-blind, placebo-controlled study of GH replacement in adults with GHD and measured cognition and sense of well-being using standardized psychometric tests before and after therapy. Forty men (median age 51 yr, range 24–64 yr) with a history of pituitary disease were randomized to GH therapy (starting dose, 10 ± 0.3 μg/kg per day: mean treatment dose, 4 ± 2 μg/kg per day) vs. placebo for 18 months, and GH doses were adjusted according to serum insulin growth factor-I levels. At baseline, the patients displayed a full-scale intelligence quotient (IQ) score nearly 1 sd above the normal mean. Mean scores on all cognitive tests fell within normal limits, and on many tests, fell above the mean. On tests of verbal learning and delayed visual memory, mean test scores fell below the mean (although within normal limits), suggestive of a relative compromise in the area of memory performance. Following 18 months of GH replacement therapy, there were no significant changes in cognitive function or quality of life. We conclude that acquired GHD in adult men is not associated with significant alterations in cognitive function as assessed by standardized tests, and chronic low-dose GH replacement therapy does not result in significant beneficial effects on cognitive function or quality of life. Although previous studies have suggested that GH replacement in adults with acquired GHD may improve quality of life, our data do not support the use of physiological GH replacement in GHD men for this indication." @default.
• W2042851570 created "2016-06-24" @default.
• W2042851570 creator A5034090492 @default.
• W2042851570 creator A5044481779 @default.
• W2042851570 creator A5048423424 @default.
• W2042851570 creator A5054662279 @default.
• W2042851570 creator A5060963953 @default.
• W2042851570 creator A5072357111 @default.
• W2042851570 creator A5076292783 @default.
• W2042851570 creator A5084997308 @default.
• W2042851570 date "1998-09-01" @default.
• W2042851570 modified "2023-10-11" @default.
• W2042851570 title "Effects of Physiological Growth Hormone (GH) Therapy on Cognition and Quality of Life in Patients with Adult-Onset GH Deficiency1" @default.
• W2042851570 cites W1966154291 @default.
• W2042851570 cites W1978787511 @default.
• W2042851570 cites W1988168814 @default.
• W2042851570 cites W1995707695 @default.
• W2042851570 cites W1999759703 @default.
• W2042851570 cites W2000555003 @default.
• W2042851570 cites W2006074731 @default.
• W2042851570 cites W2021368986 @default.
• W2042851570 cites W2031243308 @default.
• W2042851570 cites W2037846018 @default.
• W2042851570 cites W2050963313 @default.
• W2042851570 cites W2052515706 @default.
• W2042851570 cites W2096034058 @default.
• W2042851570 cites W2098999072 @default.
• W2042851570 cites W2111528719 @default.
• W2042851570 cites W2158139052 @default.
• W2042851570 cites W4249920490 @default.
• W2042851570 doi "https://doi.org/10.1210/jcem.83.9.5112" @default.
• W2042851570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9745423" @default.
• W2042851570 hasPublicationYear "1998" @default.
• W2042851570 type Work @default.
• W2042851570 sameAs 2042851570 @default.
• W2042851570 citedByCount "74" @default.
• W2042851570 countsByYear W20428515702012 @default.
• W2042851570 countsByYear W20428515702013 @default.
• W2042851570 countsByYear W20428515702014 @default.
• W2042851570 countsByYear W20428515702015 @default.
• W2042851570 countsByYear W20428515702017 @default.
• W2042851570 countsByYear W20428515702018 @default.
• W2042851570 countsByYear W20428515702019 @default.
• W2042851570 countsByYear W20428515702020 @default.
• W2042851570 countsByYear W20428515702021 @default.
• W2042851570 countsByYear W20428515702022 @default.
• W2042851570 crossrefType "journal-article" @default.
• W2042851570 hasAuthorship W2042851570A5034090492 @default.
• W2042851570 hasAuthorship W2042851570A5044481779 @default.
• W2042851570 hasAuthorship W2042851570A5048423424 @default.
• W2042851570 hasAuthorship W2042851570A5054662279 @default.
• W2042851570 hasAuthorship W2042851570A5060963953 @default.
• W2042851570 hasAuthorship W2042851570A5072357111 @default.
• W2042851570 hasAuthorship W2042851570A5076292783 @default.
• W2042851570 hasAuthorship W2042851570A5084997308 @default.
• W2042851570 hasBestOaLocation W20428515701 @default.
• W2042851570 hasConcept C118552586 @default.
• W2042851570 hasConcept C120863210 @default.
• W2042851570 hasConcept C126322002 @default.
• W2042851570 hasConcept C134018914 @default.
• W2042851570 hasConcept C142724271 @default.
• W2042851570 hasConcept C147583825 @default.
• W2042851570 hasConcept C159110408 @default.
• W2042851570 hasConcept C169900460 @default.
• W2042851570 hasConcept C204787440 @default.
• W2042851570 hasConcept C27081682 @default.
• W2042851570 hasConcept C2779279991 @default.
• W2042851570 hasConcept C2779951463 @default.
• W2042851570 hasConcept C2780159708 @default.
• W2042851570 hasConcept C71924100 @default.
• W2042851570 hasConceptScore W2042851570C118552586 @default.
• W2042851570 hasConceptScore W2042851570C120863210 @default.
• W2042851570 hasConceptScore W2042851570C126322002 @default.
• W2042851570 hasConceptScore W2042851570C134018914 @default.
• W2042851570 hasConceptScore W2042851570C142724271 @default.
• W2042851570 hasConceptScore W2042851570C147583825 @default.
• W2042851570 hasConceptScore W2042851570C159110408 @default.
• W2042851570 hasConceptScore W2042851570C169900460 @default.
• W2042851570 hasConceptScore W2042851570C204787440 @default.
• W2042851570 hasConceptScore W2042851570C27081682 @default.
• W2042851570 hasConceptScore W2042851570C2779279991 @default.
• W2042851570 hasConceptScore W2042851570C2779951463 @default.
• W2042851570 hasConceptScore W2042851570C2780159708 @default.
• W2042851570 hasConceptScore W2042851570C71924100 @default.
• W2042851570 hasIssue "9" @default.
• W2042851570 hasLocation W20428515701 @default.
• W2042851570 hasLocation W20428515702 @default.
• W2042851570 hasOpenAccess W2042851570 @default.
• W2042851570 hasPrimaryLocation W20428515701 @default.
• W2042851570 hasRelatedWork W1512226674 @default.
• W2042851570 hasRelatedWork W1960877678 @default.
• W2042851570 hasRelatedWork W2001893919 @default.
• W2042851570 hasRelatedWork W2027757116 @default.
• W2042851570 hasRelatedWork W2055648105 @default.
• W2042851570 hasRelatedWork W2083434745 @default.
• W2042851570 hasRelatedWork W2120147367 @default.
• W2042851570 hasRelatedWork W2156250868 @default.
• W2042851570 hasRelatedWork W2170604430 @default.

• next