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- W2042859126 abstract "Specific binding of [3H]nimodipine to membranes from rat ventricle and guinea pig ileal longitudinal smooth muscle was studied. Dissociation constants were 0.24 and 0.12 nM, and the maximal number of binding sites were 0.4 and 0.75 pmol/mg protein for cardiac and smooth muscle, respectively. The values obtained for both types of muscle were similar to those obtained for [3H]nitrendipine binding, as were the potencies of a series of dihydropyridines for competing with [3H]nimodipine. These results support the hypothesis that the binding site characterized is that mediating the pharmacological effects of these compounds." @default.
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- W2042859126 date "1982-08-01" @default.
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- W2042859126 title "Binding of [3H]nimodipine to cardiac and smooth muscle membranes" @default.
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- W2042859126 doi "https://doi.org/10.1016/0014-2999(82)90511-8" @default.
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