FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042861570> ?p ?o ?g. }

• W2042861570 endingPage "643" @default.
• W2042861570 startingPage "634" @default.
• W2042861570 abstract "We have investigated the effects of bFGF on both the FSH-induced LH receptor expression and cAMP production in cultured rat granulosa cells. Concentrations of pure FGF, from 10(-12) M to 10(-10) M, progressively inhibit the stimulatory actions of FSH with an ED50 of approximately 4 x 10(-12) M for both parameters. Higher FGF concentrations, from 4 x 10(-10) M to 10(-8) M, lead to a gradual reduction of the growth factor inhibitory effect. The effects of FGF are more prominent on the modulation of LH receptors than on the FSH-induced cAMP production. Moreover, FGF impairs the LH receptor formation induced by cholera toxin or 8-Bromo-cAMP, indicating that the growth factor also acts at a step distal to cAMP formation. The inhibitory effect of FGF on LH receptor expression increases during the entire course of granulosa cell differentiation, from 24 to 96 h, and is not due to variations in cell number or viability, but rather to a change in the content of LH receptors with no significant modification of binding affinity (KD congruent to 0.8 x 10(-10) M). These results suggest that bFGF may acutely regulate the capacity of granulosa cells to differentiate upon FSH stimulation and to respond to LH during the ovarian follicular maturation." @default.
• W2042861570 created "2016-06-24" @default.
• W2042861570 creator A5027988512 @default.
• W2042861570 creator A5055965666 @default.
• W2042861570 date "1988-10-01" @default.
• W2042861570 modified "2023-10-01" @default.
• W2042861570 title "Fibroblast growth factor regulates the expression of luteinizing hormone receptors in cultured rat granulosa cells" @default.
• W2042861570 cites W1490958709 @default.
• W2042861570 cites W1523485594 @default.
• W2042861570 cites W1550914515 @default.
• W2042861570 cites W1565755747 @default.
• W2042861570 cites W1964839077 @default.
• W2042861570 cites W1973983380 @default.
• W2042861570 cites W1983327325 @default.
• W2042861570 cites W1985394131 @default.
• W2042861570 cites W1995509096 @default.
• W2042861570 cites W1996315568 @default.
• W2042861570 cites W2010833294 @default.
• W2042861570 cites W2017440399 @default.
• W2042861570 cites W2021283573 @default.
• W2042861570 cites W2022109629 @default.
• W2042861570 cites W2033458917 @default.
• W2042861570 cites W2037812119 @default.
• W2042861570 cites W2051036831 @default.
• W2042861570 cites W2060572191 @default.
• W2042861570 cites W2061107904 @default.
• W2042861570 cites W2061230824 @default.
• W2042861570 cites W2061782885 @default.
• W2042861570 cites W2064982147 @default.
• W2042861570 cites W2065647047 @default.
• W2042861570 cites W2068304855 @default.
• W2042861570 cites W2074269777 @default.
• W2042861570 cites W2079198737 @default.
• W2042861570 cites W2083158575 @default.
• W2042861570 cites W2087774836 @default.
• W2042861570 cites W2098706903 @default.
• W2042861570 cites W2124974256 @default.
• W2042861570 cites W4211208200 @default.
• W2042861570 doi "https://doi.org/10.1016/s0006-291x(88)80890-8" @default.
• W2042861570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2847713" @default.
• W2042861570 hasPublicationYear "1988" @default.
• W2042861570 type Work @default.
• W2042861570 sameAs 2042861570 @default.
• W2042861570 citedByCount "32" @default.
• W2042861570 countsByYear W20428615702012 @default.
• W2042861570 countsByYear W20428615702013 @default.
• W2042861570 crossrefType "journal-article" @default.
• W2042861570 hasAuthorship W2042861570A5027988512 @default.
• W2042861570 hasAuthorship W2042861570A5055965666 @default.
• W2042861570 hasConcept C126322002 @default.
• W2042861570 hasConcept C134018914 @default.
• W2042861570 hasConcept C170493617 @default.
• W2042861570 hasConcept C185592680 @default.
• W2042861570 hasConcept C187785154 @default.
• W2042861570 hasConcept C24998067 @default.
• W2042861570 hasConcept C2775960820 @default.
• W2042861570 hasConcept C2777203538 @default.
• W2042861570 hasConcept C2778575703 @default.
• W2042861570 hasConcept C2779279165 @default.
• W2042861570 hasConcept C2780536345 @default.
• W2042861570 hasConcept C29390026 @default.
• W2042861570 hasConcept C71315377 @default.
• W2042861570 hasConcept C71924100 @default.
• W2042861570 hasConcept C74373430 @default.
• W2042861570 hasConcept C86803240 @default.
• W2042861570 hasConceptScore W2042861570C126322002 @default.
• W2042861570 hasConceptScore W2042861570C134018914 @default.
• W2042861570 hasConceptScore W2042861570C170493617 @default.
• W2042861570 hasConceptScore W2042861570C185592680 @default.
• W2042861570 hasConceptScore W2042861570C187785154 @default.
• W2042861570 hasConceptScore W2042861570C24998067 @default.
• W2042861570 hasConceptScore W2042861570C2775960820 @default.
• W2042861570 hasConceptScore W2042861570C2777203538 @default.
• W2042861570 hasConceptScore W2042861570C2778575703 @default.
• W2042861570 hasConceptScore W2042861570C2779279165 @default.
• W2042861570 hasConceptScore W2042861570C2780536345 @default.
• W2042861570 hasConceptScore W2042861570C29390026 @default.
• W2042861570 hasConceptScore W2042861570C71315377 @default.
• W2042861570 hasConceptScore W2042861570C71924100 @default.
• W2042861570 hasConceptScore W2042861570C74373430 @default.
• W2042861570 hasConceptScore W2042861570C86803240 @default.
• W2042861570 hasIssue "2" @default.
• W2042861570 hasLocation W20428615701 @default.
• W2042861570 hasLocation W20428615702 @default.
• W2042861570 hasOpenAccess W2042861570 @default.
• W2042861570 hasPrimaryLocation W20428615701 @default.
• W2042861570 hasRelatedWork W1987919126 @default.
• W2042861570 hasRelatedWork W1990896009 @default.
• W2042861570 hasRelatedWork W1991634850 @default.
• W2042861570 hasRelatedWork W2003569090 @default.
• W2042861570 hasRelatedWork W2017440399 @default.
• W2042861570 hasRelatedWork W2046079731 @default.
• W2042861570 hasRelatedWork W2057602894 @default.
• W2042861570 hasRelatedWork W2070883738 @default.
• W2042861570 hasRelatedWork W2133682560 @default.
• W2042861570 hasRelatedWork W2170775580 @default.
• W2042861570 hasVolume "156" @default.
• W2042861570 isParatext "false" @default.

• next