Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042875434> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2042875434 endingPage "39" @default.
- W2042875434 startingPage "35" @default.
- W2042875434 abstract "Elevated levels of bile acids are thought to play an important role in the renal failure of patients with obstructive jaundice undergoing surgery. In contrast, ursodeoxycholic acid (UDA) is widely used to improve cholestasis and has been proposed as protective bile acids and antioxidant. The present study employs kidney fragments to determine the role of reactive oxygen species (ROS) in the mechanism of toxicity of hydrophobic bile acids and to determine the nephroprotectant properties of UDA against the hydrophobic bile acids. The hydrophobic bile acids chenodeoxycholic (200 microM) and deoxycholic acid (200 microM) significantly (P<0.05) increased lactate dehydrogenase leakage (LDH) from glomerular fragments from 2.7+/-0.4 to 5.03+/-0.23 and 4.66+/-0.37 (micromol NADH consumed/min/mg protein) for chenodeoxycholic and deoxycholic acid respectively. Preincubating the fragments with UDA (500 microM) did not prevent the leakage of LDH caused by the bile acids. The level of lipid peroxidation was not increased in fragments exposed to either ursodeoxycholic (0-500 microM), lithocholic (0-100 microM), chenodeoxycholic (0-500 microM) or deoxycholic acid (0-500 microM). Furthermore UDA (500 microM) did not prevent the increase in lipid peroxidation caused by tert-butyl hydroperoxide (0-1000 microM) in the fragments. These results suggest that hydrophobic bile acids do not cause lipid peroxidation in kidney fragments and that UDA is neither capable of preventing the loss of membrane integrity induced by hydrophobic bile acids or acting as an antioxidant in kidney fragments." @default.
- W2042875434 created "2016-06-24" @default.
- W2042875434 creator A5010036753 @default.
- W2042875434 creator A5011402095 @default.
- W2042875434 creator A5090495485 @default.
- W2042875434 date "1999-01-01" @default.
- W2042875434 modified "2023-09-27" @default.
- W2042875434 title "The role of ursodeoxycholic acid in bile acid-mediated kidney fragment toxicity" @default.
- W2042875434 cites W1590457525 @default.
- W2042875434 cites W1637148891 @default.
- W2042875434 cites W1978367775 @default.
- W2042875434 cites W1981846085 @default.
- W2042875434 cites W2000881470 @default.
- W2042875434 cites W2019804003 @default.
- W2042875434 cites W2036433609 @default.
- W2042875434 cites W2037359977 @default.
- W2042875434 cites W2060388420 @default.
- W2042875434 cites W2063361661 @default.
- W2042875434 cites W2065751076 @default.
- W2042875434 cites W2086708964 @default.
- W2042875434 cites W2095801297 @default.
- W2042875434 cites W2096657801 @default.
- W2042875434 cites W2100345391 @default.
- W2042875434 cites W2103635868 @default.
- W2042875434 cites W2123037352 @default.
- W2042875434 cites W2128635872 @default.
- W2042875434 cites W2143993280 @default.
- W2042875434 cites W2168811983 @default.
- W2042875434 cites W2184631836 @default.
- W2042875434 cites W2346430498 @default.
- W2042875434 cites W34937259 @default.
- W2042875434 cites W65249248 @default.
- W2042875434 doi "https://doi.org/10.1016/s0940-2993(99)80057-8" @default.
- W2042875434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10048711" @default.
- W2042875434 hasPublicationYear "1999" @default.
- W2042875434 type Work @default.
- W2042875434 sameAs 2042875434 @default.
- W2042875434 citedByCount "1" @default.
- W2042875434 crossrefType "journal-article" @default.
- W2042875434 hasAuthorship W2042875434A5010036753 @default.
- W2042875434 hasAuthorship W2042875434A5011402095 @default.
- W2042875434 hasAuthorship W2042875434A5090495485 @default.
- W2042875434 hasConcept C126322002 @default.
- W2042875434 hasConcept C178790620 @default.
- W2042875434 hasConcept C181199279 @default.
- W2042875434 hasConcept C185592680 @default.
- W2042875434 hasConcept C2777318727 @default.
- W2042875434 hasConcept C2778004101 @default.
- W2042875434 hasConcept C2778593092 @default.
- W2042875434 hasConcept C2779399885 @default.
- W2042875434 hasConcept C2780420665 @default.
- W2042875434 hasConcept C2780749602 @default.
- W2042875434 hasConcept C2780829032 @default.
- W2042875434 hasConcept C2780965833 @default.
- W2042875434 hasConcept C2781089062 @default.
- W2042875434 hasConcept C29730261 @default.
- W2042875434 hasConcept C55493867 @default.
- W2042875434 hasConcept C71924100 @default.
- W2042875434 hasConceptScore W2042875434C126322002 @default.
- W2042875434 hasConceptScore W2042875434C178790620 @default.
- W2042875434 hasConceptScore W2042875434C181199279 @default.
- W2042875434 hasConceptScore W2042875434C185592680 @default.
- W2042875434 hasConceptScore W2042875434C2777318727 @default.
- W2042875434 hasConceptScore W2042875434C2778004101 @default.
- W2042875434 hasConceptScore W2042875434C2778593092 @default.
- W2042875434 hasConceptScore W2042875434C2779399885 @default.
- W2042875434 hasConceptScore W2042875434C2780420665 @default.
- W2042875434 hasConceptScore W2042875434C2780749602 @default.
- W2042875434 hasConceptScore W2042875434C2780829032 @default.
- W2042875434 hasConceptScore W2042875434C2780965833 @default.
- W2042875434 hasConceptScore W2042875434C2781089062 @default.
- W2042875434 hasConceptScore W2042875434C29730261 @default.
- W2042875434 hasConceptScore W2042875434C55493867 @default.
- W2042875434 hasConceptScore W2042875434C71924100 @default.
- W2042875434 hasIssue "1" @default.
- W2042875434 hasLocation W20428754341 @default.
- W2042875434 hasLocation W20428754342 @default.
- W2042875434 hasOpenAccess W2042875434 @default.
- W2042875434 hasPrimaryLocation W20428754341 @default.
- W2042875434 hasRelatedWork W1610781402 @default.
- W2042875434 hasRelatedWork W1979948452 @default.
- W2042875434 hasRelatedWork W2034106555 @default.
- W2042875434 hasRelatedWork W2042875434 @default.
- W2042875434 hasRelatedWork W2104435845 @default.
- W2042875434 hasRelatedWork W2116889951 @default.
- W2042875434 hasRelatedWork W2343604647 @default.
- W2042875434 hasRelatedWork W2348665323 @default.
- W2042875434 hasRelatedWork W2419754872 @default.
- W2042875434 hasRelatedWork W2436584027 @default.
- W2042875434 hasVolume "51" @default.
- W2042875434 isParatext "false" @default.
- W2042875434 isRetracted "false" @default.
- W2042875434 magId "2042875434" @default.
- W2042875434 workType "article" @default.