FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042876746> ?p ?o ?g. }

• W2042876746 endingPage "702" @default.
• W2042876746 startingPage "691" @default.
• W2042876746 abstract "The intra-cellular level of tumor suppressor protein p53 is tightly controlled by an autoregulatory feedback loop between the protein and its negative regulator MDM2. The role of MDM2 in down-regulating the p53 response in unstressed conditions and in the post-stress recovery phase is well documented. However, interplay between the N-terminal phosphorylations and C-terminal acetylations of p53 in this context remains unclear. Here, we show that an MAR binding protein SMAR1 interacts with MDM2 and the Ser15 phosphorylated form of p53, forming a ternary complex in the post stress-recovery phase. This triple complex formation between p53, MDM2 and SMAR1 results in recruitment of HDAC1 to deacetylate p53. The deacetylated p53 binds poorly to the target promoter (p21), which results in switching off the p53 response, essential for re-entry into the cell cycle. Interestingly, the knock-down of SMAR1 using siRNA leads to a prolonged cell-cycle arrest in the post stress recovery phase due to ablation of p53-MDM2-HDAC1 interaction. Thus, the results presented here for the first time highlight the role of SMAR1 in masking the active phosphorylation site of p53, enabling the deacetylation of p53 by HDAC1-MDM2 complex, thereby regulating the p53 transcriptional response during stress rescue." @default.
• W2042876746 created "2016-06-24" @default.
• W2042876746 creator A5012333107 @default.
• W2042876746 creator A5027555519 @default.
• W2042876746 creator A5030726908 @default.
• W2042876746 creator A5039558836 @default.
• W2042876746 creator A5046416885 @default.
• W2042876746 creator A5074102723 @default.
• W2042876746 creator A5091516720 @default.
• W2042876746 date "2009-05-01" @default.
• W2042876746 modified "2023-10-14" @default.
• W2042876746 title "SMAR1 Forms a Ternary Complex with p53-MDM2 and Negatively Regulates p53-mediated Transcription" @default.
• W2042876746 cites W1548972556 @default.
• W2042876746 cites W1856360008 @default.
• W2042876746 cites W1970796703 @default.
• W2042876746 cites W1976261939 @default.
• W2042876746 cites W1987536971 @default.
• W2042876746 cites W1990882829 @default.
• W2042876746 cites W1999310200 @default.
• W2042876746 cites W2003236156 @default.
• W2042876746 cites W2008193634 @default.
• W2042876746 cites W2015604190 @default.
• W2042876746 cites W2015872419 @default.
• W2042876746 cites W2021176126 @default.
• W2042876746 cites W2023424326 @default.
• W2042876746 cites W2030371377 @default.
• W2042876746 cites W2044568075 @default.
• W2042876746 cites W2048410022 @default.
• W2042876746 cites W2057087535 @default.
• W2042876746 cites W2058015944 @default.
• W2042876746 cites W2058659363 @default.
• W2042876746 cites W2058923987 @default.
• W2042876746 cites W2071555702 @default.
• W2042876746 cites W2072677280 @default.
• W2042876746 cites W2073936529 @default.
• W2042876746 cites W2074545297 @default.
• W2042876746 cites W2081184407 @default.
• W2042876746 cites W2090786961 @default.
• W2042876746 cites W2092722802 @default.
• W2042876746 cites W2099907467 @default.
• W2042876746 cites W2116755440 @default.
• W2042876746 cites W2120254637 @default.
• W2042876746 cites W2128323213 @default.
• W2042876746 cites W2135192417 @default.
• W2042876746 cites W2138282644 @default.
• W2042876746 cites W2139655205 @default.
• W2042876746 cites W2161529931 @default.
• W2042876746 cites W2165179185 @default.
• W2042876746 doi "https://doi.org/10.1016/j.jmb.2009.03.033" @default.
• W2042876746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19303885" @default.
• W2042876746 hasPublicationYear "2009" @default.
• W2042876746 type Work @default.
• W2042876746 sameAs 2042876746 @default.
• W2042876746 citedByCount "26" @default.
• W2042876746 countsByYear W20428767462012 @default.
• W2042876746 countsByYear W20428767462013 @default.
• W2042876746 countsByYear W20428767462014 @default.
• W2042876746 countsByYear W20428767462015 @default.
• W2042876746 countsByYear W20428767462016 @default.
• W2042876746 countsByYear W20428767462017 @default.
• W2042876746 countsByYear W20428767462018 @default.
• W2042876746 countsByYear W20428767462020 @default.
• W2042876746 countsByYear W20428767462021 @default.
• W2042876746 countsByYear W20428767462022 @default.
• W2042876746 countsByYear W20428767462023 @default.
• W2042876746 crossrefType "journal-article" @default.
• W2042876746 hasAuthorship W2042876746A5012333107 @default.
• W2042876746 hasAuthorship W2042876746A5027555519 @default.
• W2042876746 hasAuthorship W2042876746A5030726908 @default.
• W2042876746 hasAuthorship W2042876746A5039558836 @default.
• W2042876746 hasAuthorship W2042876746A5046416885 @default.
• W2042876746 hasAuthorship W2042876746A5074102723 @default.
• W2042876746 hasAuthorship W2042876746A5091516720 @default.
• W2042876746 hasConcept C104317684 @default.
• W2042876746 hasConcept C119157956 @default.
• W2042876746 hasConcept C11960822 @default.
• W2042876746 hasConcept C143425029 @default.
• W2042876746 hasConcept C179185449 @default.
• W2042876746 hasConcept C181199279 @default.
• W2042876746 hasConcept C190283241 @default.
• W2042876746 hasConcept C2776192174 @default.
• W2042876746 hasConcept C552990157 @default.
• W2042876746 hasConcept C55493867 @default.
• W2042876746 hasConcept C6929976 @default.
• W2042876746 hasConcept C86756495 @default.
• W2042876746 hasConcept C86803240 @default.
• W2042876746 hasConcept C95444343 @default.
• W2042876746 hasConceptScore W2042876746C104317684 @default.
• W2042876746 hasConceptScore W2042876746C119157956 @default.
• W2042876746 hasConceptScore W2042876746C11960822 @default.
• W2042876746 hasConceptScore W2042876746C143425029 @default.
• W2042876746 hasConceptScore W2042876746C179185449 @default.
• W2042876746 hasConceptScore W2042876746C181199279 @default.
• W2042876746 hasConceptScore W2042876746C190283241 @default.
• W2042876746 hasConceptScore W2042876746C2776192174 @default.
• W2042876746 hasConceptScore W2042876746C552990157 @default.
• W2042876746 hasConceptScore W2042876746C55493867 @default.
• W2042876746 hasConceptScore W2042876746C6929976 @default.

• next