Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042880985> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2042880985 endingPage "48" @default.
- W2042880985 startingPage "43" @default.
- W2042880985 abstract "Various rheological abnormalities of the blood have been widely reported in diabetes. However, it remains unclear which one affects blood flow at the level of microcirculation, an important site in the pathogenesis of diabetic microangiopathy. To differentiate which blood component leads to microcirculatory disturbances in diabetes, we studied the hemorheological properties of diabetic patients using an array flow analyzer that has microchannels simulating capillaries. Venous blood was collected from 19 diabetic patients and 24 control subjects. Three blood samples were prepared: plasma alone, erythrocyte suspension (ES) at 10% hematocrit (Ht), and erythrocyte and leukocyte suspension (ELS) having leukocyte counts of 1000/μl at 10% Ht. These samples were forced to flow through microchannels (equivalent diameter 6 μm, equivalent length 30 μm, 2600 in parallel) by applying a pressure difference of 20 cm H2O. Transit times for 100 μl of samples were measured, and the flow behavior of cells through the microchannels was recorded with a video-microscope. The transit time of ELS was 52.5 ± 6.2 sec (mean ± SD) in the diabetic group and 47.7 ± 3.3 sec in the control group; there was significant prolongation in the transit time of diabetic ELS (P= 0.005), whereas the transit times of plasma alone and ES showed no significant differences between control and diabetic groups. Leukocytes were occasionally observed to plug the microchannels during the measurements of ELS from some diabetic patients. Our results imply that reduced deformability of leukocytes in diabetes may contribute to flow disturbances in the microcirculation. Leukocytes could play a potential role in the pathogenesis of diabetic microangiopathy." @default.
- W2042880985 created "2016-06-24" @default.
- W2042880985 creator A5008754139 @default.
- W2042880985 creator A5054512097 @default.
- W2042880985 creator A5070793093 @default.
- W2042880985 creator A5072634175 @default.
- W2042880985 date "1997-07-01" @default.
- W2042880985 modified "2023-09-27" @default.
- W2042880985 title "Role of Leukocytes in Diabetic Microcirculatory Disturbances" @default.
- W2042880985 cites W1488623284 @default.
- W2042880985 cites W1977948007 @default.
- W2042880985 cites W1980229240 @default.
- W2042880985 cites W1984544134 @default.
- W2042880985 cites W2011642892 @default.
- W2042880985 cites W2023850729 @default.
- W2042880985 cites W2030392715 @default.
- W2042880985 cites W2032371975 @default.
- W2042880985 cites W2051322044 @default.
- W2042880985 cites W2052335450 @default.
- W2042880985 cites W2064742209 @default.
- W2042880985 cites W2064796506 @default.
- W2042880985 cites W2125781124 @default.
- W2042880985 cites W2145294053 @default.
- W2042880985 cites W2151461394 @default.
- W2042880985 cites W2469886606 @default.
- W2042880985 cites W4250022659 @default.
- W2042880985 doi "https://doi.org/10.1006/mvre.1997.2018" @default.
- W2042880985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9245643" @default.
- W2042880985 hasPublicationYear "1997" @default.
- W2042880985 type Work @default.
- W2042880985 sameAs 2042880985 @default.
- W2042880985 citedByCount "42" @default.
- W2042880985 countsByYear W20428809852014 @default.
- W2042880985 countsByYear W20428809852015 @default.
- W2042880985 countsByYear W20428809852016 @default.
- W2042880985 countsByYear W20428809852017 @default.
- W2042880985 countsByYear W20428809852018 @default.
- W2042880985 countsByYear W20428809852019 @default.
- W2042880985 countsByYear W20428809852021 @default.
- W2042880985 crossrefType "journal-article" @default.
- W2042880985 hasAuthorship W2042880985A5008754139 @default.
- W2042880985 hasAuthorship W2042880985A5054512097 @default.
- W2042880985 hasAuthorship W2042880985A5070793093 @default.
- W2042880985 hasAuthorship W2042880985A5072634175 @default.
- W2042880985 hasConcept C126322002 @default.
- W2042880985 hasConcept C12722491 @default.
- W2042880985 hasConcept C134018914 @default.
- W2042880985 hasConcept C142724271 @default.
- W2042880985 hasConcept C158846371 @default.
- W2042880985 hasConcept C164705383 @default.
- W2042880985 hasConcept C2776185378 @default.
- W2042880985 hasConcept C2776436680 @default.
- W2042880985 hasConcept C2776513394 @default.
- W2042880985 hasConcept C2776557347 @default.
- W2042880985 hasConcept C2777660278 @default.
- W2042880985 hasConcept C2780394083 @default.
- W2042880985 hasConcept C2780942790 @default.
- W2042880985 hasConcept C2780959883 @default.
- W2042880985 hasConcept C555293320 @default.
- W2042880985 hasConcept C71924100 @default.
- W2042880985 hasConcept C78520924 @default.
- W2042880985 hasConceptScore W2042880985C126322002 @default.
- W2042880985 hasConceptScore W2042880985C12722491 @default.
- W2042880985 hasConceptScore W2042880985C134018914 @default.
- W2042880985 hasConceptScore W2042880985C142724271 @default.
- W2042880985 hasConceptScore W2042880985C158846371 @default.
- W2042880985 hasConceptScore W2042880985C164705383 @default.
- W2042880985 hasConceptScore W2042880985C2776185378 @default.
- W2042880985 hasConceptScore W2042880985C2776436680 @default.
- W2042880985 hasConceptScore W2042880985C2776513394 @default.
- W2042880985 hasConceptScore W2042880985C2776557347 @default.
- W2042880985 hasConceptScore W2042880985C2777660278 @default.
- W2042880985 hasConceptScore W2042880985C2780394083 @default.
- W2042880985 hasConceptScore W2042880985C2780942790 @default.
- W2042880985 hasConceptScore W2042880985C2780959883 @default.
- W2042880985 hasConceptScore W2042880985C555293320 @default.
- W2042880985 hasConceptScore W2042880985C71924100 @default.
- W2042880985 hasConceptScore W2042880985C78520924 @default.
- W2042880985 hasIssue "1" @default.
- W2042880985 hasLocation W20428809851 @default.
- W2042880985 hasLocation W20428809852 @default.
- W2042880985 hasOpenAccess W2042880985 @default.
- W2042880985 hasPrimaryLocation W20428809851 @default.
- W2042880985 hasRelatedWork W1418381745 @default.
- W2042880985 hasRelatedWork W2042880985 @default.
- W2042880985 hasRelatedWork W2155091152 @default.
- W2042880985 hasRelatedWork W2256842522 @default.
- W2042880985 hasRelatedWork W2368269239 @default.
- W2042880985 hasRelatedWork W2405384099 @default.
- W2042880985 hasRelatedWork W2426001679 @default.
- W2042880985 hasRelatedWork W2460061332 @default.
- W2042880985 hasRelatedWork W2548619100 @default.
- W2042880985 hasRelatedWork W2549752407 @default.
- W2042880985 hasVolume "54" @default.
- W2042880985 isParatext "false" @default.
- W2042880985 isRetracted "false" @default.
- W2042880985 magId "2042880985" @default.
- W2042880985 workType "article" @default.