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• W2042883111 abstract "The recognition that colorectal cancer (CRC) is a heterogeneous disease in terms of clinical behaviour and response to therapy translates into an urgent need for robust molecular disease subclassifiers that can explain this heterogeneity beyond current parameters (MSI, KRAS, BRAF). Attempts to fill this gap are emerging. The Cancer Genome Atlas (TGCA) reported two main CRC groups, based on the incidence and spectrum of mutated genes, and another paper reported an EMT expression signature defined subgroup. We performed a prior free analysis of CRC heterogeneity on 1113 CRC gene expression profiles and confronted our findings to established molecular determinants and clinical, histopathological and survival data. Unsupervised clustering based on gene modules allowed us to distinguish at least five different gene expression CRC subtypes, which we call surface crypt-like, lower crypt-like, CIMP-H-like, mesenchymal and mixed. A gene set enrichment analysis combined with literature search of gene module members identified distinct biological motifs in different subtypes. The subtypes, which were not derived based on outcome, nonetheless showed differences in prognosis. Known gene copy number variations and mutations in key cancer-associated genes differed between subtypes, but the subtypes provided molecular information beyond that contained in these variables. Morphological features significantly differed between subtypes. The objective existence of the subtypes and their clinical and molecular characteristics were validated in an independent set of 720 CRC expression profiles. Our subtypes provide a novel perspective on the heterogeneity of CRC. The proposed subtypes should be further explored retrospectively on existing clinical trial datasets and, when sufficiently robust, be prospectively assessed for clinical relevance in terms of prognosis and treatment response predictive capacity. Original microarray data were uploaded to the ArrayExpress database (http://www.ebi.ac.uk/arrayexpress/) under Accession Nos E-MTAB-990 and E-MTAB-1026. © 2013 Swiss Institute of Bioinformatics. Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland." @default.
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• W2042883111 date "2013-07-08" @default.
• W2042883111 modified "2023-10-02" @default.
• W2042883111 title "Gene expression patterns unveil a new level of molecular heterogeneity in colorectal cancer" @default.
• W2042883111 cites W1496141235 @default.
• W2042883111 cites W1506160581 @default.
• W2042883111 cites W1513618424 @default.
• W2042883111 cites W1548779692 @default.
• W2042883111 cites W1969489258 @default.
• W2042883111 cites W1972301614 @default.
• W2042883111 cites W1976116300 @default.
• W2042883111 cites W1984984201 @default.
• W2042883111 cites W1989531492 @default.
• W2042883111 cites W1991113117 @default.
• W2042883111 cites W1993347240 @default.
• W2042883111 cites W1998558839 @default.
• W2042883111 cites W2001159807 @default.
• W2042883111 cites W2005494948 @default.
• W2042883111 cites W2007012192 @default.
• W2042883111 cites W2008557163 @default.
• W2042883111 cites W2009983270 @default.
• W2042883111 cites W2011217149 @default.
• W2042883111 cites W2013475854 @default.
• W2042883111 cites W2015076473 @default.
• W2042883111 cites W2025227137 @default.
• W2042883111 cites W2030945062 @default.
• W2042883111 cites W2031735410 @default.
• W2042883111 cites W2033126020 @default.
• W2042883111 cites W2036204636 @default.
• W2042883111 cites W2039777025 @default.
• W2042883111 cites W2040815621 @default.
• W2042883111 cites W2042126900 @default.
• W2042883111 cites W2042159815 @default.
• W2042883111 cites W2054022354 @default.
• W2042883111 cites W2065059240 @default.
• W2042883111 cites W2074279306 @default.
• W2042883111 cites W2075464225 @default.
• W2042883111 cites W2075962214 @default.
• W2042883111 cites W2081098333 @default.
• W2042883111 cites W2090175366 @default.
• W2042883111 cites W2091372427 @default.
• W2042883111 cites W2096283457 @default.
• W2042883111 cites W2103045139 @default.
• W2042883111 cites W2103547637 @default.
• W2042883111 cites W2105829583 @default.
• W2042883111 cites W2109062146 @default.
• W2042883111 cites W2109144433 @default.
• W2042883111 cites W2117424291 @default.
• W2042883111 cites W2118017554 @default.
• W2042883111 cites W2122825543 @default.
• W2042883111 cites W2123998733 @default.
• W2042883111 cites W2124003081 @default.
• W2042883111 cites W2127575026 @default.
• W2042883111 cites W2127848815 @default.
• W2042883111 cites W2131683480 @default.
• W2042883111 cites W2132165198 @default.
• W2042883111 cites W2133093811 @default.
• W2042883111 cites W2133465414 @default.
• W2042883111 cites W2133899877 @default.
• W2042883111 cites W2135715423 @default.
• W2042883111 cites W2137028370 @default.
• W2042883111 cites W2139889887 @default.
• W2042883111 cites W2146303969 @default.
• W2042883111 cites W2147343434 @default.
• W2042883111 cites W2148092441 @default.
• W2042883111 cites W2151457918 @default.
• W2042883111 cites W2156247618 @default.
• W2042883111 cites W2157910818 @default.
• W2042883111 cites W2158217645 @default.
• W2042883111 cites W2159342260 @default.
• W2042883111 cites W2160697532 @default.
• W2042883111 cites W2164274198 @default.
• W2042883111 cites W2165087323 @default.
• W2042883111 cites W2165389801 @default.
• W2042883111 cites W2172097353 @default.
• W2042883111 cites W2262414037 @default.
• W2042883111 cites W2787894218 @default.
• W2042883111 cites W4213257593 @default.
• W2042883111 cites W4252961770 @default.
• W2042883111 doi "https://doi.org/10.1002/path.4212" @default.
• W2042883111 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3840702" @default.
• W2042883111 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23836465" @default.
• W2042883111 hasPublicationYear "2013" @default.
• W2042883111 type Work @default.

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