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- W2042898051 abstract "Clinicalmicrobiology ispoised tomove into adynamic ageby embracing molecular diagnostic techniques, such as polymerase chain reaction–based amplification techniques and whole-genome sequencing (WGS). These technologies will revolutionize data acquisition for theranostics and the tracking of outbreaks. Whole-genome sequencing originally proved its worth through investigations of infectious agents.1 In this issue of JAMA Internal Medicine, Reuter et al2 now advocate WGS for routine diagnostics and public health microbiology. These ideas arenot as far-fetchedas they may initially sound. Although the cost and time to conductWGSwouldhaveoncebeenprohibitive,abacterialWGS can be performed for less than $100 in 1 day’s time.Moreover, the computational systems forperforming theanalytics on the WGSdata allow for rapid turnaround times.Collectively, these metrics make WGS competitive with any technology, including traditional methods of culturing bacteria. Although there arenocommercialWGSanalytics thatcould integratewithstandard laboratory informationsystemsnow,suchtoolswill bedeveloped that canaccess cloud-basedcomputing resources containingglobalstraindatabasesannotatedwithrespect toclinical origins, spread, and associated symptoms." @default.
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- W2042898051 date "2013-08-12" @default.
- W2042898051 modified "2023-10-18" @default.
- W2042898051 title "The Time Is Now for Gene- and Genome-Based Bacterial Diagnostics" @default.
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- W2042898051 doi "https://doi.org/10.1001/jamainternmed.2013.7042" @default.
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