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• W2042931375 abstract "There are uncertainties regarding the role of sex steroids in sexual development and reproduction of gastropods, leading to the recent doubts as to whether organotin compounds do inhibit steroidogenic enzymes in these species. These doubts have led us to suspect that organotin compounds may affect other target molecules, particularly signal transduction molecules or secondary mediators of steroid hormone and lipid synthesis/metabolism. Therefore, we have studied the effects of TBT exposure through food on acute steroidogenesis, PPARs and CYP3A responses in the presence and absence of a cyclic AMP (cAMP) activator, forskolin. Two experiments were performed. Firstly, juvenile salmon were force-fed once with diet containing TBT doses (0.1, 1 and 10 mg/kg fish) dissolved in ethanol and sampled after 72 h. Secondly, fish exposed to solvent control and 10 mg/kg TBT for 72 h were transferred to new tanks and exposed to waterborne forskolin (200 μg/L) for 2 and 4 h. Our data show that juvenile salmon force-fed TBT showed modulations of multiple biological responses in interrenal tissues that include, steroidogenesis (cAMP/PKA activities; StAR and P450scc mRNA, and plasma cortisol), and mRNA for peroxisome proliferator-activated receptor (PPAR) isoforms (α, β, γ), acyl-CoA oxidase-1 (ACOX1) and CYP3A/PXR (pregnan X receptor). In addition, forskolin produced differential effects on these responses both singly and also in combination with TBT. Overall, combined forskolin and TBT exposure produced higher effects compared with TBT exposure alone, for most of the responses (cortisol, PPARβ, ACOX1 and CYP3A). Interestingly, forskolin produced PPAR isoform-specific effects when given singly or in combination with TBT. Several TBT mediated toxicity in fish that includes thymus reduction, decrease in numbers of lymphocytes, inhibition of gonad development and masculinization, including the imposex phenomenon have been reported. When these effects are considered with the present findings, it suggests that studies on mechanisms of action or field studies may reveal endocrine, reproductive or other effects of TBT at lower concentrations than those reported to date from subchronic tests of fishes. Since the metabolic fate of organotin compounds may contribute to the toxicity of these chemicals, the present findings may represent some new aspects of TBT toxicity not previously reported." @default.
• W2042931375 created "2016-06-24" @default.
• W2042931375 creator A5027444080 @default.
• W2042931375 creator A5073530658 @default.
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• W2042931375 date "2010-04-01" @default.
• W2042931375 modified "2023-10-10" @default.
• W2042931375 title "Modulation of acute steroidogenesis, peroxisome proliferator-activated receptors and CYP3A/PXR in salmon interrenal tissues by tributyltin and the second messenger activator, forskolin" @default.
• W2042931375 cites W1480092883 @default.
• W2042931375 cites W1488922245 @default.
• W2042931375 cites W1675030349 @default.
• W2042931375 cites W1712951338 @default.
• W2042931375 cites W1922937805 @default.
• W2042931375 cites W1965692638 @default.
• W2042931375 cites W1973984331 @default.
• W2042931375 cites W1985206799 @default.
• W2042931375 cites W1987420904 @default.
• W2042931375 cites W1996696969 @default.
• W2042931375 cites W2000182700 @default.
• W2042931375 cites W2000581994 @default.
• W2042931375 cites W2003693592 @default.
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• W2042931375 cites W2010404866 @default.
• W2042931375 cites W2011908174 @default.
• W2042931375 cites W2012144992 @default.
• W2042931375 cites W2013175577 @default.
• W2042931375 cites W2018583688 @default.
• W2042931375 cites W2025823859 @default.
• W2042931375 cites W2025852957 @default.
• W2042931375 cites W2037077714 @default.
• W2042931375 cites W2037360988 @default.
• W2042931375 cites W2040393790 @default.
• W2042931375 cites W2042127427 @default.
• W2042931375 cites W2047316488 @default.
• W2042931375 cites W2050131628 @default.
• W2042931375 cites W2050207944 @default.
• W2042931375 cites W2050698392 @default.
• W2042931375 cites W2055865544 @default.
• W2042931375 cites W2058244668 @default.
• W2042931375 cites W2061451325 @default.
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• W2042931375 cites W2068172765 @default.
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• W2042931375 cites W2071298971 @default.
• W2042931375 cites W2076452736 @default.
• W2042931375 cites W2079641593 @default.
• W2042931375 cites W2084462922 @default.
• W2042931375 cites W2087986742 @default.
• W2042931375 cites W2088454205 @default.
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• W2042931375 doi "https://doi.org/10.1016/j.cbi.2010.03.005" @default.
• W2042931375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20211155" @default.
• W2042931375 hasPublicationYear "2010" @default.
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