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- W2042932336 abstract "A general synthetic strategy toward α- or β-galactosylceramides and their analogues from 3-azido-2-O-benzyl-1-O-(4-methoxybenzyl)butane-1,2,4-triol is described. The key steps for the installation of the main lipid chain are either a diasteroselective alkynylation reaction yielding the 4R stereocenter of phytosphingosine or a Wittig olefination generating the trans double bond of sphingosine. The methodology allows the preparation of different glycolipids with variations in the structure of the sphingoid base. In particular, three α-GalCer-related compounds have been synthesized and evaluated for their ability to activate CD1d-restricted T-cells." @default.
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- W2042932336 date "2007-09-01" @default.
- W2042932336 modified "2023-09-24" @default.
- W2042932336 title "A General and Stereoselective Route to α- or β-Galactosphingolipids via a Common Four-Carbon Building Block" @default.
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- W2042932336 doi "https://doi.org/10.1021/jo070849z" @default.
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