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- W2042933834 abstract "In Parkinson's disease (PD) many motor and non-motor symptoms are difficult to explain in terms of a purely ascending degeneration process as described by Braak. This essay proposes phylogenetic considerations for consolidating the multidimensional elements of PD. Subtle clinical analysis paired with ethological comparisons as well as patho-anatomical data suggests that disrupted automatic gait control, olfactory deficits, selected visual deficits, impaired emotional face recognition, and REM sleep behavior disorder could be due to dysfunction of phylogenetically ancient networks. Neuroanatomical and behavioral findings lead to a reconsideration of the basal ganglia, to be viewed as the nuclear core of a widely distributed neural network that arborizes throughout the primordial core of the neuraxis, including the brainstem. Fragility of the resulting multiple, closed, ancillary loops that link brainstem and forebrain components of the basal ganglia may be a nodal point, pivotal to the pathogenesis of PD. Other primitive neural networks, such as those located at cardiac or gastro-intestinal levels, may share the same vulnerability. Such a network-based hypothesis overrides the need of a fixed temporal ordering of symptoms based on putative caudal-cephalic propagation patterns of pathological lesions. It also creates testable, secondary hypotheses such as differential gene expression in different neural networks, potential early epigenetic influences, concepts of overuse or maladaptation of primitive networks to the constraints of adult life, and system frailty due to irreparable mitochondrial exhaustion in highly energy consuming postmitotic cells." @default.
- W2042933834 created "2016-06-24" @default.
- W2042933834 creator A5024165143 @default.
- W2042933834 creator A5025368869 @default.
- W2042933834 date "2012-03-01" @default.
- W2042933834 modified "2023-10-02" @default.
- W2042933834 title "Parkinson's disease: Acquired frailty of archaic neural networks?" @default.
- W2042933834 cites W1483007279 @default.
- W2042933834 cites W1491231112 @default.
- W2042933834 cites W149812667 @default.
- W2042933834 cites W1521385720 @default.
- W2042933834 cites W152231878 @default.
- W2042933834 cites W1657459197 @default.
- W2042933834 cites W1665095741 @default.
- W2042933834 cites W1905711341 @default.
- W2042933834 cites W1964668480 @default.
- W2042933834 cites W1970565325 @default.
- W2042933834 cites W1971588250 @default.
- W2042933834 cites W1971892997 @default.
- W2042933834 cites W1973001146 @default.
- W2042933834 cites W1974433124 @default.
- W2042933834 cites W1974807964 @default.
- W2042933834 cites W1975728052 @default.
- W2042933834 cites W1976645698 @default.
- W2042933834 cites W1985580589 @default.
- W2042933834 cites W1985972499 @default.
- W2042933834 cites W1986083929 @default.
- W2042933834 cites W1988786764 @default.
- W2042933834 cites W1989672532 @default.
- W2042933834 cites W1990326740 @default.
- W2042933834 cites W1990744953 @default.
- W2042933834 cites W1991672513 @default.
- W2042933834 cites W1993268131 @default.
- W2042933834 cites W1994948661 @default.
- W2042933834 cites W1998893768 @default.
- W2042933834 cites W2000164389 @default.
- W2042933834 cites W2003924082 @default.
- W2042933834 cites W2005331929 @default.
- W2042933834 cites W2007491035 @default.
- W2042933834 cites W2007746109 @default.
- W2042933834 cites W2008114685 @default.
- W2042933834 cites W2008201895 @default.
- W2042933834 cites W2009128664 @default.
- W2042933834 cites W2009318929 @default.
- W2042933834 cites W2010055704 @default.
- W2042933834 cites W2010998231 @default.
- W2042933834 cites W2011441557 @default.
- W2042933834 cites W2016433712 @default.
- W2042933834 cites W2020777374 @default.
- W2042933834 cites W2021111992 @default.
- W2042933834 cites W2021784772 @default.
- W2042933834 cites W2023785308 @default.
- W2042933834 cites W2026982903 @default.
- W2042933834 cites W2027494808 @default.
- W2042933834 cites W2028082659 @default.
- W2042933834 cites W2028690674 @default.
- W2042933834 cites W2031995010 @default.
- W2042933834 cites W2035026525 @default.
- W2042933834 cites W2037557796 @default.
- W2042933834 cites W2038819786 @default.
- W2042933834 cites W2044571150 @default.
- W2042933834 cites W2044908785 @default.
- W2042933834 cites W2045694767 @default.
- W2042933834 cites W2046198995 @default.
- W2042933834 cites W2046589157 @default.
- W2042933834 cites W2046895759 @default.
- W2042933834 cites W2047554354 @default.
- W2042933834 cites W2049103344 @default.
- W2042933834 cites W2050128450 @default.
- W2042933834 cites W2053219794 @default.
- W2042933834 cites W2053258863 @default.
- W2042933834 cites W2054709014 @default.
- W2042933834 cites W2055437008 @default.
- W2042933834 cites W2056061278 @default.
- W2042933834 cites W2056304503 @default.
- W2042933834 cites W2058914023 @default.
- W2042933834 cites W2059029335 @default.
- W2042933834 cites W2060756968 @default.
- W2042933834 cites W2062656862 @default.
- W2042933834 cites W2065699023 @default.
- W2042933834 cites W2068008366 @default.
- W2042933834 cites W2068111891 @default.
- W2042933834 cites W2068261317 @default.
- W2042933834 cites W2069826159 @default.
- W2042933834 cites W2070770997 @default.
- W2042933834 cites W2070966985 @default.
- W2042933834 cites W2073449985 @default.
- W2042933834 cites W2074052524 @default.
- W2042933834 cites W2074954595 @default.
- W2042933834 cites W2078638840 @default.
- W2042933834 cites W2088821245 @default.
- W2042933834 cites W2089086690 @default.
- W2042933834 cites W2089745615 @default.
- W2042933834 cites W2089791510 @default.
- W2042933834 cites W2091467822 @default.
- W2042933834 cites W2091686113 @default.
- W2042933834 cites W2093585116 @default.
- W2042933834 cites W2094152331 @default.