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- W2042954338 abstract "Abstract The dissociation of the 7 S oligomer of nerve growth factor prepared from mouse submaxillary gland has been studied by sedimentation velocity as a function of added NaCl and/or EDTA at pH 6.8 in phosphate buffer. Dilution with or without EDTA results in a symmetrical dissociation to the 4.5 S protomer, in agreement with previous work. In the presence of increasing NaCl concentration the 7 S nerve growth factor oligomer undergoes limited dissociation which is characterized by complex boundary formation and the presence of a stable intermediate (weight-average s20, w for the system of 4. 1 S at 2 n NaCl). The dissociation mode is probably asymmetrical in NaCl with the system resulting in an equilibrium mixture of γ and α2β complex (s20,w about 4.7 S). The removal of zinc ion by EDTA causes only a small change in the native equilibrium but destabilizes the complex with respect to salt-mediated dissociation, leading to complete dissociation to subunits at relatively low concentrations of NaCl. Zinc ion also promotes reassociation of mixtures of isolated α + β or β + γ subunits. Thus, a structural role of zinc ion in stabilizing subunit interactions, probably α − β or β − γ, is proposed. The specificity of the interactions with zinc ion and the specificity of the ionic interactions stabilizing the oligomer are further evidence for a biological specificity, if not function, of the oligomer." @default.
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- W2042954338 date "1980-12-01" @default.
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- W2042954338 title "Subunit interactions of nerve growth factor: Sedimentation analysis of the dissociation of the 7 S oligomer promoted by salt and ethylenediaminetetraacetate" @default.
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- W2042954338 doi "https://doi.org/10.1016/0003-9861(80)90124-1" @default.
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