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• W2042954510 abstract "<i>S</i>-¹¹C-methyl-L-cysteine (¹¹C-MCYS), an analog of <i>S</i>-¹¹C-methyl-L-methionine (¹¹C-MET), can potentially serve as an amino acid PET tracer for tumor imaging. The aim of this study was to investigate the radiosynthesis and perform a biologic evaluation of ¹¹C-MCYS as a tumor imaging tracer. The results of the first human PET study are reported. <b>Methods:</b>¹¹C-MCYS was prepared by ¹¹C-methylation of the precursor L-cysteine with ¹¹CH₃I and purification on commercial C18 cartridges. In vitro competitive inhibition experiments were performed with Hepa1–6 hepatoma cell lines, and biodistribution of ¹¹C-MCYS was determined in normal mice. The incorporation of ¹¹C-MCYS into tissue proteins was investigated. In vivo ¹¹C-MCYS uptake studies were performed on hepatocellular carcinoma–bearing nude mice and inflammation models and compared with ¹¹C-MET PET and ¹⁸F-FDG PET. In a human PET study, a patient with a recurrence of glioma after surgery was examined with ¹¹C-MCYS PET and ¹⁸F-FDG PET. <b>Results:</b> The uncorrected radiochemical yield of ¹¹C-MCYS from ¹¹CH₃I was more than 50% with a synthesis time of 2 min, the radiochemical purity of ¹¹C-MCYS was more than 99%, and the enantiomeric purity was more than 90%. In vitro studies showed that ¹¹C-MCYS transport was mediated through transport system L. Biodistribution studies demonstrated high uptake of ¹¹C-MCYS in the liver, stomach wall, and heart and low uptake of ¹¹C-MCYS in the brain. There was higher accumulation of ¹¹C-MCYS in the tumor than in the muscles. The tumor-to-muscle and inflammatory lesion–to–muscle ratios were 7.27 and 1.62, respectively, for ¹¹C-MCYS, 5.08 and 3.88, respectively, for ¹⁸F-FDG, and 4.26 and 2.28, respectively, for ¹¹C-MET at 60 min after injection. Almost no ¹¹C-MCYS was incorporated into proteins. For the patient PET study, high uptake of ¹¹C-MCYS with true-positive results, but low uptake of ¹⁸F-FDG with false-negative results, was found in the recurrent glioma. <b>Conclusion:</b> Automated synthesis of ¹¹C-MCYS is easy to perform. ¹¹C-MCYS is superior to ¹¹C-MET and ¹⁸F-FDG in the differentiation of tumor from inflammation and seems to have potential as an oncologic PET tracer for the diagnosis of solid tumors." @default.
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• W2042954510 date "2011-01-13" @default.
• W2042954510 modified "2023-09-27" @default.
• W2042954510 title "<i>S</i>-¹¹C-Methyl-L-Cysteine: A New Amino Acid PET Tracer for Cancer Imaging" @default.
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• W2042954510 doi "https://doi.org/10.2967/jnumed.110.081349" @default.
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