FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042961073> ?p ?o ?g. }

• W2042961073 endingPage "113" @default.
• W2042961073 startingPage "107" @default.
• W2042961073 abstract "OBJECTIVES The endocrine manisfestation of puberty, nocturnal pulsatile secretion of gonadotrophins precedes the physical manifestations by 2 years. Whether gonadal steroids and inhibin have a role to play in the regulation of pulsatile gonadotrophin release is unclear. The agonadal model, girls with Turner's syndrome (TS), has been used to determine the role of the hypothalamic pulse generator in the ontogeny of gonadotrophin secretion in man. We evaluated the ontogeny of gonadotrophin secretion in TS girls with respect to amplitude and frequency and compared these results to those obtained in a group of normal girls. The effects of treatment with ethinyloestradiol (EE2) or oxandrolone (OX) on parameters of gonadotrophin secretion were also evaluated. PATIENTS We studied 32 girls with TS, aged 4.3–12.4 years. All were prepubertal at the start of the study and longterm follow up revealed that none entered spontaneous puberty. The pulse amplitude and frequency was evaluated and compared to the results obtained in 23 normal girls, aged 4.9–12.8 years who acted as controls. MEASUREMENTS Samples were taken at 20 minute intervals for 24 h for the measurement of serum concentrations of luteinising (LH) and follicle stimulating (FSH) hormones. The girls were than randomized to receive EE2 or OX and were then re-admitted 6 months into the course of the treatment for a repeat 24 h serum profile of LH and FSH levels. RESULTS The girls with TS showed a clearly defined dominant pulse periodicity of 180 min and that in the normal cohort was 160–220 min. The girls with TS had an increased oscillatory activity between 120 and 260 min compared to the normal. Mean 24 h serum gonadotrophin concentration in TS girls was always higher than in the normal cohort. The inflection points of the fitted polynominal regression equation relating sex hormone concentration with age was similar for the two groups. EE2 lead to a significant change in pulse periodicity in TS girls but OX had no significant effect on the pulse periodicity. CONCLUSION These results demonstrate that girls with Turner syndrome have gonadotrophin pulse periodicity in the prepubertal years similar to those of normal girls. The oscillatory activity was much greater in girls with Turner syndrome at all ages in the prepubertal years, suggesting a role for the ovary in modulating gonadotrophin secretion in the prepubertal years. Our data confirm that in girls with Turner syndrome the normal pattern of gonadotrophin secretion evolving with time is preserved." @default.
• W2042961073 created "2016-06-24" @default.
• W2042961073 creator A5022173648 @default.
• W2042961073 creator A5040738036 @default.
• W2042961073 creator A5052523491 @default.
• W2042961073 creator A5089455595 @default.
• W2042961073 date "1998-07-01" @default.
• W2042961073 modified "2023-10-11" @default.
• W2042961073 title "Gonadotrophin pulsatility in girls with the Turner syndrome: modulation by exogenous sex steroids" @default.
• W2042961073 cites W1971565476 @default.
• W2042961073 cites W1971975900 @default.
• W2042961073 cites W2003882616 @default.
• W2042961073 cites W2012899599 @default.
• W2042961073 cites W2027341277 @default.
• W2042961073 cites W2032627582 @default.
• W2042961073 cites W2043151080 @default.
• W2042961073 cites W2059252082 @default.
• W2042961073 cites W2068905948 @default.
• W2042961073 cites W2077392823 @default.
• W2042961073 cites W2087941795 @default.
• W2042961073 cites W2090510664 @default.
• W2042961073 cites W2104675247 @default.
• W2042961073 cites W2118202495 @default.
• W2042961073 cites W2135348351 @default.
• W2042961073 cites W2158067213 @default.
• W2042961073 cites W2158312495 @default.
• W2042961073 cites W2339721589 @default.
• W2042961073 cites W4214737381 @default.
• W2042961073 cites W4317650622 @default.
• W2042961073 doi "https://doi.org/10.1046/j.1365-2265.1998.00495.x" @default.
• W2042961073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9797854" @default.
• W2042961073 hasPublicationYear "1998" @default.
• W2042961073 type Work @default.
• W2042961073 sameAs 2042961073 @default.
• W2042961073 citedByCount "18" @default.
• W2042961073 countsByYear W20429610732015 @default.
• W2042961073 countsByYear W20429610732016 @default.
• W2042961073 countsByYear W20429610732019 @default.
• W2042961073 crossrefType "journal-article" @default.
• W2042961073 hasAuthorship W2042961073A5022173648 @default.
• W2042961073 hasAuthorship W2042961073A5040738036 @default.
• W2042961073 hasAuthorship W2042961073A5052523491 @default.
• W2042961073 hasAuthorship W2042961073A5089455595 @default.
• W2042961073 hasConcept C126322002 @default.
• W2042961073 hasConcept C134018914 @default.
• W2042961073 hasConcept C2778575703 @default.
• W2042961073 hasConcept C2778782382 @default.
• W2042961073 hasConcept C2779279165 @default.
• W2042961073 hasConcept C2779279991 @default.
• W2042961073 hasConcept C2779683239 @default.
• W2042961073 hasConcept C2779733885 @default.
• W2042961073 hasConcept C2984496839 @default.
• W2042961073 hasConcept C71315377 @default.
• W2042961073 hasConcept C71924100 @default.
• W2042961073 hasConcept C79191276 @default.
• W2042961073 hasConcept C86803240 @default.
• W2042961073 hasConceptScore W2042961073C126322002 @default.
• W2042961073 hasConceptScore W2042961073C134018914 @default.
• W2042961073 hasConceptScore W2042961073C2778575703 @default.
• W2042961073 hasConceptScore W2042961073C2778782382 @default.
• W2042961073 hasConceptScore W2042961073C2779279165 @default.
• W2042961073 hasConceptScore W2042961073C2779279991 @default.
• W2042961073 hasConceptScore W2042961073C2779683239 @default.
• W2042961073 hasConceptScore W2042961073C2779733885 @default.
• W2042961073 hasConceptScore W2042961073C2984496839 @default.
• W2042961073 hasConceptScore W2042961073C71315377 @default.
• W2042961073 hasConceptScore W2042961073C71924100 @default.
• W2042961073 hasConceptScore W2042961073C79191276 @default.
• W2042961073 hasConceptScore W2042961073C86803240 @default.
• W2042961073 hasIssue "1" @default.
• W2042961073 hasLocation W20429610731 @default.
• W2042961073 hasLocation W20429610732 @default.
• W2042961073 hasOpenAccess W2042961073 @default.
• W2042961073 hasPrimaryLocation W20429610731 @default.
• W2042961073 hasRelatedWork W1966056255 @default.
• W2042961073 hasRelatedWork W1984614377 @default.
• W2042961073 hasRelatedWork W2038342185 @default.
• W2042961073 hasRelatedWork W2077606717 @default.
• W2042961073 hasRelatedWork W2083697871 @default.
• W2042961073 hasRelatedWork W2085326155 @default.
• W2042961073 hasRelatedWork W2145915957 @default.
• W2042961073 hasRelatedWork W2152789511 @default.
• W2042961073 hasRelatedWork W2170979158 @default.
• W2042961073 hasRelatedWork W2412524349 @default.
• W2042961073 hasVolume "49" @default.
• W2042961073 isParatext "false" @default.
• W2042961073 isRetracted "false" @default.
• W2042961073 magId "2042961073" @default.
• W2042961073 workType "article" @default.