Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042998324> ?p ?o ?g. }
- W2042998324 endingPage "555" @default.
- W2042998324 startingPage "548" @default.
- W2042998324 abstract "BackgroundFetal stress has been linked to adult atherosclerosis, obesity, and diabetes. Epidemiology studies have associated fetal exposure to maternal smoking and postnatal exposure to environmental tobacco smoke (ETS) with increased asthma risk.ObjectiveWe tested the hypothesis, in a mouse model of asthma, that in utero ETS exposure alters airway function and respiratory immune responses in adults.MethodsPregnant Balb/c mice were exposed daily to ETS or HEPA-filtered air (AIR). Offspring inhaled aerosolized ovalbumin (OVA) or saline in weeks 7–8. Regardless of whether they inhaled OVA or saline, mice were sensitized by OVA injections in weeks 11 and 13 followed by OVA aerosol challenge in weeks 14–15. At three time points, we assessed OVA-specific serum immunoglobins, bronchoalveolar lavage cells and cytokines, lung and nasal histopathology, and airway hyperresponsiveness (AHR).ResultsAt 6 weeks, we found no significant differences between in utero ETS and AIR mice. At 10 weeks, following OVA aerosol, ETS mice displayed greater AHR than AIR mice (α = 0.05), unaccompanied by changes in histopathology, cytokine profile, or antibody levels. At 15 weeks, mice that had inhaled saline in weeks 7–8 developed airway inflammation: eosinophilia (α = 0.05), interleukin-5 (α = 0.05), and AHR (α = 0.05) were greater in ETS mice than in AIR mice. Mice that had inhaled OVA in weeks 7–8 demonstrated no airway inflammation after sensitization and challenge.ConclusionIn utero ETS exposure exacerbates subsequent adult responses to initial allergen exposure." @default.
- W2042998324 created "2016-06-24" @default.
- W2042998324 creator A5017827064 @default.
- W2042998324 creator A5030606422 @default.
- W2042998324 creator A5035587766 @default.
- W2042998324 creator A5039082203 @default.
- W2042998324 creator A5045228018 @default.
- W2042998324 creator A5074528066 @default.
- W2042998324 date "2007-04-01" @default.
- W2042998324 modified "2023-10-02" @default.
- W2042998324 title "<i>In Utero</i> Exposure to Environmental Tobacco Smoke Potentiates Adult Responses to Allergen in BALB/c Mice" @default.
- W2042998324 cites W1526525248 @default.
- W2042998324 cites W1532147512 @default.
- W2042998324 cites W1539208643 @default.
- W2042998324 cites W1539696212 @default.
- W2042998324 cites W1571433528 @default.
- W2042998324 cites W1615320989 @default.
- W2042998324 cites W1833176788 @default.
- W2042998324 cites W1957538709 @default.
- W2042998324 cites W1964260173 @default.
- W2042998324 cites W1964605889 @default.
- W2042998324 cites W1967153266 @default.
- W2042998324 cites W1977970997 @default.
- W2042998324 cites W1978044676 @default.
- W2042998324 cites W1978733316 @default.
- W2042998324 cites W1987325365 @default.
- W2042998324 cites W1990969922 @default.
- W2042998324 cites W1995674079 @default.
- W2042998324 cites W1995905836 @default.
- W2042998324 cites W1999991326 @default.
- W2042998324 cites W2004279822 @default.
- W2042998324 cites W2008355478 @default.
- W2042998324 cites W2013665799 @default.
- W2042998324 cites W2024069455 @default.
- W2042998324 cites W2025435237 @default.
- W2042998324 cites W2026859905 @default.
- W2042998324 cites W2029786587 @default.
- W2042998324 cites W2031971960 @default.
- W2042998324 cites W2032441389 @default.
- W2042998324 cites W2032765714 @default.
- W2042998324 cites W2033425349 @default.
- W2042998324 cites W2034888399 @default.
- W2042998324 cites W2038379636 @default.
- W2042998324 cites W2038448781 @default.
- W2042998324 cites W2040281845 @default.
- W2042998324 cites W2041523507 @default.
- W2042998324 cites W2045097329 @default.
- W2042998324 cites W2045832454 @default.
- W2042998324 cites W2056303724 @default.
- W2042998324 cites W2065462657 @default.
- W2042998324 cites W2065973180 @default.
- W2042998324 cites W2066868347 @default.
- W2042998324 cites W2068220762 @default.
- W2042998324 cites W2071124023 @default.
- W2042998324 cites W2074288442 @default.
- W2042998324 cites W2077180370 @default.
- W2042998324 cites W2079893720 @default.
- W2042998324 cites W2095961670 @default.
- W2042998324 cites W2118643159 @default.
- W2042998324 cites W2119836546 @default.
- W2042998324 cites W2125382956 @default.
- W2042998324 cites W2126118351 @default.
- W2042998324 cites W2127594954 @default.
- W2042998324 cites W2129431737 @default.
- W2042998324 cites W2134624251 @default.
- W2042998324 cites W2135172357 @default.
- W2042998324 cites W2135298542 @default.
- W2042998324 cites W2141791068 @default.
- W2042998324 cites W2142151481 @default.
- W2042998324 cites W2150674341 @default.
- W2042998324 cites W2153231621 @default.
- W2042998324 cites W2155605798 @default.
- W2042998324 cites W2155679715 @default.
- W2042998324 cites W2161362125 @default.
- W2042998324 cites W2162657772 @default.
- W2042998324 cites W2164901146 @default.
- W2042998324 cites W2166925955 @default.
- W2042998324 cites W4210243988 @default.
- W2042998324 cites W46532993 @default.
- W2042998324 doi "https://doi.org/10.1289/ehp.9780" @default.
- W2042998324 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1852677" @default.
- W2042998324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17450223" @default.
- W2042998324 hasPublicationYear "2007" @default.
- W2042998324 type Work @default.
- W2042998324 sameAs 2042998324 @default.
- W2042998324 citedByCount "58" @default.
- W2042998324 countsByYear W20429983242012 @default.
- W2042998324 countsByYear W20429983242013 @default.
- W2042998324 countsByYear W20429983242014 @default.
- W2042998324 countsByYear W20429983242015 @default.
- W2042998324 countsByYear W20429983242016 @default.
- W2042998324 countsByYear W20429983242017 @default.
- W2042998324 countsByYear W20429983242018 @default.
- W2042998324 countsByYear W20429983242020 @default.
- W2042998324 countsByYear W20429983242021 @default.
- W2042998324 countsByYear W20429983242022 @default.
- W2042998324 countsByYear W20429983242023 @default.
- W2042998324 crossrefType "journal-article" @default.