FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043001543> ?p ?o ?g. }

• W2043001543 endingPage "477" @default.
• W2043001543 startingPage "463" @default.
• W2043001543 abstract "Cathepsin D is a member of the lysosomal aspartic proteinases and has been claimed to play a crucial role in the breakdown of larval tissues during anuran metamorphosis. The present study aimed to characterize the gene of anuran cathepsin D as an approach for elucidating the molecular mechanism of involution of larval tissues. Three overlapping cDNA of Xenopus cathepsin D were amplified by the polymerase chain reaction and were cloned, which covered 590 bp, 355 bp and 790 bp sequences of the region between two enzyme active sites, a 5'-end and 3'-end regions of the gene, respectively. Altogether they revealed 1.6 kbp encoding 422 amino acids of the enzyme. Xenopus cathepsin D showed about 60% homology to mammalian enzymes at the amino acid sequence level. Northern blot analyses revealed the gradual increase of cathepsin D transcripts in the tail during prometamorphosis, reaching a peak at stage 61 and 62. Thyroid hormone notably enhanced the signals of northern blotting of the tail. The in situ hybridization histochemistry showed that both epidermal cells in the basal layer and subepidermal mesenchymal cells embedded in the thick layer of collagen fibers produce high levels of mRNA of cathepsin D in response to thyroid hormone, suggesting active contribution of the cells closely located at the basement membrane to the breakdown of tail tissues." @default.
• W2043001543 created "2016-06-24" @default.
• W2043001543 creator A5046135191 @default.
• W2043001543 creator A5068299173 @default.
• W2043001543 creator A5087434980 @default.
• W2043001543 date "1995-10-01" @default.
• W2043001543 modified "2023-09-27" @default.
• W2043001543 title "Characterization of gene of anuran cathepsin D as a metamorphosis-associated enzyme" @default.
• W2043001543 cites W1180108146 @default.
• W2043001543 cites W121824892 @default.
• W2043001543 cites W1557168768 @default.
• W2043001543 cites W1572600466 @default.
• W2043001543 cites W1574964940 @default.
• W2043001543 cites W1577183978 @default.
• W2043001543 cites W1583559371 @default.
• W2043001543 cites W1600238761 @default.
• W2043001543 cites W1663165115 @default.
• W2043001543 cites W1694091219 @default.
• W2043001543 cites W1957450506 @default.
• W2043001543 cites W1962551859 @default.
• W2043001543 cites W1965735992 @default.
• W2043001543 cites W1973291166 @default.
• W2043001543 cites W1973556902 @default.
• W2043001543 cites W1974639601 @default.
• W2043001543 cites W1978587648 @default.
• W2043001543 cites W1981474173 @default.
• W2043001543 cites W1993101179 @default.
• W2043001543 cites W1998902933 @default.
• W2043001543 cites W1999693114 @default.
• W2043001543 cites W2002712696 @default.
• W2043001543 cites W2015502095 @default.
• W2043001543 cites W2016995602 @default.
• W2043001543 cites W2018289835 @default.
• W2043001543 cites W2020506488 @default.
• W2043001543 cites W2020652041 @default.
• W2043001543 cites W2020879230 @default.
• W2043001543 cites W2024810164 @default.
• W2043001543 cites W2038199097 @default.
• W2043001543 cites W2043828563 @default.
• W2043001543 cites W2071680839 @default.
• W2043001543 cites W2083436346 @default.
• W2043001543 cites W2086119240 @default.
• W2043001543 cites W2089220628 @default.
• W2043001543 cites W2096258929 @default.
• W2043001543 cites W2100837269 @default.
• W2043001543 cites W2110314216 @default.
• W2043001543 cites W2112823160 @default.
• W2043001543 cites W2130929794 @default.
• W2043001543 cites W2139222706 @default.
• W2043001543 cites W2140734047 @default.
• W2043001543 cites W2257003752 @default.
• W2043001543 cites W2258087888 @default.
• W2043001543 cites W2409953317 @default.
• W2043001543 cites W2602769894 @default.
• W2043001543 doi "https://doi.org/10.1046/j.1440-169x.1995.t01-4-00001.x" @default.
• W2043001543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37282339" @default.
• W2043001543 hasPublicationYear "1995" @default.
• W2043001543 type Work @default.
• W2043001543 sameAs 2043001543 @default.
• W2043001543 citedByCount "13" @default.
• W2043001543 countsByYear W20430015432012 @default.
• W2043001543 countsByYear W20430015432015 @default.
• W2043001543 crossrefType "journal-article" @default.
• W2043001543 hasAuthorship W2043001543A5046135191 @default.
• W2043001543 hasAuthorship W2043001543A5068299173 @default.
• W2043001543 hasAuthorship W2043001543A5087434980 @default.
• W2043001543 hasBestOaLocation W20430015431 @default.
• W2043001543 hasConcept C104317684 @default.
• W2043001543 hasConcept C105580179 @default.
• W2043001543 hasConcept C133307689 @default.
• W2043001543 hasConcept C153911025 @default.
• W2043001543 hasConcept C167844969 @default.
• W2043001543 hasConcept C173633252 @default.
• W2043001543 hasConcept C177707886 @default.
• W2043001543 hasConcept C181199279 @default.
• W2043001543 hasConcept C187882448 @default.
• W2043001543 hasConcept C2779535977 @default.
• W2043001543 hasConcept C2780034444 @default.
• W2043001543 hasConcept C28021979 @default.
• W2043001543 hasConcept C515207424 @default.
• W2043001543 hasConcept C51618164 @default.
• W2043001543 hasConcept C55493867 @default.
• W2043001543 hasConcept C81439078 @default.
• W2043001543 hasConcept C85265743 @default.
• W2043001543 hasConcept C86803240 @default.
• W2043001543 hasConceptScore W2043001543C104317684 @default.
• W2043001543 hasConceptScore W2043001543C105580179 @default.
• W2043001543 hasConceptScore W2043001543C133307689 @default.
• W2043001543 hasConceptScore W2043001543C153911025 @default.
• W2043001543 hasConceptScore W2043001543C167844969 @default.
• W2043001543 hasConceptScore W2043001543C173633252 @default.
• W2043001543 hasConceptScore W2043001543C177707886 @default.
• W2043001543 hasConceptScore W2043001543C181199279 @default.
• W2043001543 hasConceptScore W2043001543C187882448 @default.
• W2043001543 hasConceptScore W2043001543C2779535977 @default.
• W2043001543 hasConceptScore W2043001543C2780034444 @default.
• W2043001543 hasConceptScore W2043001543C28021979 @default.
• W2043001543 hasConceptScore W2043001543C515207424 @default.

• next