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• W2043008520 endingPage "2398" @default.
• W2043008520 startingPage "2392" @default.
• W2043008520 abstract "Abstract Leukotriene B 4 (LTB 4 ) has been shown to affect several interleukin (IL)‐linked functions of human lymphocytes. In this study, we investigated whether LTB 4 regulates IL‐5 generation from human T cells and subsequently modulates eosinophil functions. Preincubation of T cells with very low concentrations (10 −12 to 10 −8 M ) of LTB 4 induced concentration‐dependent IL‐5 production, the event occurring after the first 24 h of cultivation. However, direct action of LTB 4 to IL‐5 generation is strictly dependent on a preincubation with appropriate concentration of LTB 4 . In contrast, the stereoisomer of LTB 4 ,5S,12S‐dihydroxy‐6,8,10,14‐eicosatetraenoic acid showed no enhancement of IL‐5 production. IL‐5 released from LTB 4 ‐primed T cells elicited sustained viability of mature eosinophils and reduced the content of eosinophil cationic protein in their crystalloid matrix by degranulation. These data suggest that LTB 4 induces bioactive IL‐5 production from T cells and that the released IL‐5 modulates eosinophil functions which might play a crucial role in eosinophil‐linked allergic inflammatory process." @default.
• W2043008520 created "2016-06-24" @default.
• W2043008520 creator A5018169774 @default.
• W2043008520 creator A5039029648 @default.
• W2043008520 date "1993-10-01" @default.
• W2043008520 modified "2023-10-17" @default.
• W2043008520 title "Leukotriene B₄ induces interleukin 5 generation from human T lymphocytes" @default.
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• W2043008520 doi "https://doi.org/10.1002/eji.1830231003" @default.
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