FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043008718> ?p ?o ?g. }

• W2043008718 endingPage "808" @default.
• W2043008718 startingPage "797" @default.
• W2043008718 abstract "The role of oxygen in the induction of cellular damages during re-oxygenation of hypoxic hearts was studied in isolated Langendorff perfused rat hearts. An increase in the period of hypoxia of up to 80 min resulted in a decrease in both superoxide dismutase and glutathione peroxidase activity. This decrease continued when the hearts perfused in hypoxia for periods of 40 and 60 min were re-oxygenated for an additional 20 min. Under these conditions, re-oxygenation caused an increase in lipid peroxidation which was evaluated as malondialdehyde formation. In comparison to aerobic hearts, the cellular contents of acid soluble thiol groups, insoluble thiol groups and reduced glutathione were all decreased by hypoxia, while oxidized glutathione remained unchanged. The re-admission of oxygen to hypoxic hearts produced a further reduction in thiol groups and reduced glutathione. In contrast to well-oxygenated rat hearts, perfusion with substrate-free hypoxic medium resulted in a marked release of reduced glutathione into coronary effluents, which also continued after re-oxygenation. In hypoxia the release of oxidized glutathione began after 30 min of perfusion and slightly increased during the next 60 min of hypoxia. Re-oxygenation after 60 min of hypoxia did not enhance hypoxic oxidized glutathione release. These results suggest that re-oxygenation is able to induce lipid peroxidative damage in cardiac rat tissue when hypoxic substrate-free perfusions had previously reduced the cellular defensive mechanisms capable of neutralizing the toxic reactions mediated by oxygen metabolites." @default.
• W2043008718 created "2016-06-24" @default.
• W2043008718 creator A5018776423 @default.
• W2043008718 creator A5021047101 @default.
• W2043008718 creator A5042339894 @default.
• W2043008718 date "1980-08-01" @default.
• W2043008718 modified "2023-10-16" @default.
• W2043008718 title "Role of oxygen in the cellular damage induced by re-oxygenation of hypoxic heart" @default.
• W2043008718 cites W1599860938 @default.
• W2043008718 cites W1963518346 @default.
• W2043008718 cites W1988241811 @default.
• W2043008718 cites W1995187283 @default.
• W2043008718 cites W1997410588 @default.
• W2043008718 cites W2002449229 @default.
• W2043008718 cites W2007064404 @default.
• W2043008718 cites W2010690232 @default.
• W2043008718 cites W2012835119 @default.
• W2043008718 cites W2013805538 @default.
• W2043008718 cites W2013912698 @default.
• W2043008718 cites W2016725675 @default.
• W2043008718 cites W2027712360 @default.
• W2043008718 cites W2048054089 @default.
• W2043008718 cites W2051909997 @default.
• W2043008718 cites W2063576996 @default.
• W2043008718 cites W2085168553 @default.
• W2043008718 cites W2088866343 @default.
• W2043008718 cites W2101518804 @default.
• W2043008718 cites W2128635872 @default.
• W2043008718 cites W2168207032 @default.
• W2043008718 cites W2235701907 @default.
• W2043008718 cites W2279148071 @default.
• W2043008718 cites W2283958521 @default.
• W2043008718 cites W2408488879 @default.
• W2043008718 cites W2442761512 @default.
• W2043008718 cites W44020636 @default.
• W2043008718 cites W2067073313 @default.
• W2043008718 cites W2086643536 @default.
• W2043008718 doi "https://doi.org/10.1016/0022-2828(80)90081-4" @default.
• W2043008718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7420425" @default.
• W2043008718 hasPublicationYear "1980" @default.
• W2043008718 type Work @default.
• W2043008718 sameAs 2043008718 @default.
• W2043008718 citedByCount "528" @default.
• W2043008718 countsByYear W20430087182012 @default.
• W2043008718 countsByYear W20430087182013 @default.
• W2043008718 countsByYear W20430087182014 @default.
• W2043008718 countsByYear W20430087182015 @default.
• W2043008718 countsByYear W20430087182016 @default.
• W2043008718 countsByYear W20430087182017 @default.
• W2043008718 countsByYear W20430087182018 @default.
• W2043008718 countsByYear W20430087182019 @default.
• W2043008718 countsByYear W20430087182020 @default.
• W2043008718 countsByYear W20430087182021 @default.
• W2043008718 countsByYear W20430087182022 @default.
• W2043008718 countsByYear W20430087182023 @default.
• W2043008718 crossrefType "journal-article" @default.
• W2043008718 hasAuthorship W2043008718A5018776423 @default.
• W2043008718 hasAuthorship W2043008718A5021047101 @default.
• W2043008718 hasAuthorship W2043008718A5042339894 @default.
• W2043008718 hasConcept C126322002 @default.
• W2043008718 hasConcept C134018914 @default.
• W2043008718 hasConcept C146957229 @default.
• W2043008718 hasConcept C178790620 @default.
• W2043008718 hasConcept C181199279 @default.
• W2043008718 hasConcept C185592680 @default.
• W2043008718 hasConcept C2775838275 @default.
• W2043008718 hasConcept C2776151105 @default.
• W2043008718 hasConcept C2778401633 @default.
• W2043008718 hasConcept C2778760513 @default.
• W2043008718 hasConcept C2780829032 @default.
• W2043008718 hasConcept C2781324293 @default.
• W2043008718 hasConcept C538909803 @default.
• W2043008718 hasConcept C540031477 @default.
• W2043008718 hasConcept C55493867 @default.
• W2043008718 hasConcept C70289976 @default.
• W2043008718 hasConcept C71924100 @default.
• W2043008718 hasConcept C7836513 @default.
• W2043008718 hasConcept C86803240 @default.
• W2043008718 hasConceptScore W2043008718C126322002 @default.
• W2043008718 hasConceptScore W2043008718C134018914 @default.
• W2043008718 hasConceptScore W2043008718C146957229 @default.
• W2043008718 hasConceptScore W2043008718C178790620 @default.
• W2043008718 hasConceptScore W2043008718C181199279 @default.
• W2043008718 hasConceptScore W2043008718C185592680 @default.
• W2043008718 hasConceptScore W2043008718C2775838275 @default.
• W2043008718 hasConceptScore W2043008718C2776151105 @default.
• W2043008718 hasConceptScore W2043008718C2778401633 @default.
• W2043008718 hasConceptScore W2043008718C2778760513 @default.
• W2043008718 hasConceptScore W2043008718C2780829032 @default.
• W2043008718 hasConceptScore W2043008718C2781324293 @default.
• W2043008718 hasConceptScore W2043008718C538909803 @default.
• W2043008718 hasConceptScore W2043008718C540031477 @default.
• W2043008718 hasConceptScore W2043008718C55493867 @default.
• W2043008718 hasConceptScore W2043008718C70289976 @default.
• W2043008718 hasConceptScore W2043008718C71924100 @default.
• W2043008718 hasConceptScore W2043008718C7836513 @default.
• W2043008718 hasConceptScore W2043008718C86803240 @default.
• W2043008718 hasIssue "8" @default.

• next