FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043012583> ?p ?o ?g. }

• W2043012583 endingPage "524" @default.
• W2043012583 startingPage "519" @default.
• W2043012583 abstract "The discovery of ceramide kinase (CerK), which phosphorylates ceramide (Cer) to ceramide 1-phisphate (C1P), established a new pathway for Cer metabolism. Among mouse tissues, brain contains the highest CerK activity. In this study, we found that CerK is highly expressed in cerebellar Purkinje cells. Since Purkinje cells are important for motor-related behaviors, we generated CerK-null mice and performed behavioral analyses. The CerK-null mice were healthy, and displayed no histological abnormalities. The mice lost CerK activity completely, suggesting that CerK is the only enzyme that phosphorylate Cer. However, cellular C1P levels were not different between the CerK-null and wild-type mice, indicating the presence of other C1P-producing pathway. The general motor-coordination was not impaired in the CerK-null mice, but emotional behavior was slightly affected. Our findings suggest that CerK is not necessary for survival at an individual level, but might be involved in higher brain function related to emotion." @default.
• W2043012583 created "2016-06-24" @default.
• W2043012583 creator A5000412945 @default.
• W2043012583 creator A5006381064 @default.
• W2043012583 creator A5010830182 @default.
• W2043012583 creator A5015523421 @default.
• W2043012583 creator A5027902657 @default.
• W2043012583 creator A5034561662 @default.
• W2043012583 creator A5037191860 @default.
• W2043012583 creator A5048279225 @default.
• W2043012583 creator A5051658165 @default.
• W2043012583 creator A5054945833 @default.
• W2043012583 creator A5062324757 @default.
• W2043012583 creator A5071818138 @default.
• W2043012583 date "2007-11-01" @default.
• W2043012583 modified "2023-10-01" @default.
• W2043012583 title "The generation and behavioral analysis of ceramide kinase-null mice, indicating a function in cerebellar Purkinje cells" @default.
• W2043012583 cites W1514747902 @default.
• W2043012583 cites W1635474458 @default.
• W2043012583 cites W1777151528 @default.
• W2043012583 cites W1972917887 @default.
• W2043012583 cites W1981690170 @default.
• W2043012583 cites W1986841583 @default.
• W2043012583 cites W1989050444 @default.
• W2043012583 cites W1990858807 @default.
• W2043012583 cites W2002940566 @default.
• W2043012583 cites W2016746327 @default.
• W2043012583 cites W2023384909 @default.
• W2043012583 cites W2067098811 @default.
• W2043012583 cites W2084177469 @default.
• W2043012583 cites W2087487347 @default.
• W2043012583 cites W2088302139 @default.
• W2043012583 cites W2127202162 @default.
• W2043012583 cites W2131870085 @default.
• W2043012583 cites W2133011371 @default.
• W2043012583 cites W2140477475 @default.
• W2043012583 cites W2159301814 @default.
• W2043012583 doi "https://doi.org/10.1016/j.bbrc.2007.09.010" @default.
• W2043012583 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17888878" @default.
• W2043012583 hasPublicationYear "2007" @default.
• W2043012583 type Work @default.
• W2043012583 sameAs 2043012583 @default.
• W2043012583 citedByCount "38" @default.
• W2043012583 countsByYear W20430125832012 @default.
• W2043012583 countsByYear W20430125832013 @default.
• W2043012583 countsByYear W20430125832014 @default.
• W2043012583 countsByYear W20430125832015 @default.
• W2043012583 countsByYear W20430125832016 @default.
• W2043012583 countsByYear W20430125832017 @default.
• W2043012583 countsByYear W20430125832018 @default.
• W2043012583 countsByYear W20430125832019 @default.
• W2043012583 countsByYear W20430125832020 @default.
• W2043012583 countsByYear W20430125832022 @default.
• W2043012583 countsByYear W20430125832023 @default.
• W2043012583 crossrefType "journal-article" @default.
• W2043012583 hasAuthorship W2043012583A5000412945 @default.
• W2043012583 hasAuthorship W2043012583A5006381064 @default.
• W2043012583 hasAuthorship W2043012583A5010830182 @default.
• W2043012583 hasAuthorship W2043012583A5015523421 @default.
• W2043012583 hasAuthorship W2043012583A5027902657 @default.
• W2043012583 hasAuthorship W2043012583A5034561662 @default.
• W2043012583 hasAuthorship W2043012583A5037191860 @default.
• W2043012583 hasAuthorship W2043012583A5048279225 @default.
• W2043012583 hasAuthorship W2043012583A5051658165 @default.
• W2043012583 hasAuthorship W2043012583A5054945833 @default.
• W2043012583 hasAuthorship W2043012583A5062324757 @default.
• W2043012583 hasAuthorship W2043012583A5071818138 @default.
• W2043012583 hasConcept C169760540 @default.
• W2043012583 hasConcept C185592680 @default.
• W2043012583 hasConcept C190283241 @default.
• W2043012583 hasConcept C2777851122 @default.
• W2043012583 hasConcept C2779652256 @default.
• W2043012583 hasConcept C55493867 @default.
• W2043012583 hasConcept C86803240 @default.
• W2043012583 hasConcept C95444343 @default.
• W2043012583 hasConceptScore W2043012583C169760540 @default.
• W2043012583 hasConceptScore W2043012583C185592680 @default.
• W2043012583 hasConceptScore W2043012583C190283241 @default.
• W2043012583 hasConceptScore W2043012583C2777851122 @default.
• W2043012583 hasConceptScore W2043012583C2779652256 @default.
• W2043012583 hasConceptScore W2043012583C55493867 @default.
• W2043012583 hasConceptScore W2043012583C86803240 @default.
• W2043012583 hasConceptScore W2043012583C95444343 @default.
• W2043012583 hasIssue "3" @default.
• W2043012583 hasLocation W20430125831 @default.
• W2043012583 hasLocation W20430125832 @default.
• W2043012583 hasOpenAccess W2043012583 @default.
• W2043012583 hasPrimaryLocation W20430125831 @default.
• W2043012583 hasRelatedWork W1492356485 @default.
• W2043012583 hasRelatedWork W1969158591 @default.
• W2043012583 hasRelatedWork W1972090215 @default.
• W2043012583 hasRelatedWork W1977563244 @default.
• W2043012583 hasRelatedWork W1994004807 @default.
• W2043012583 hasRelatedWork W2073165828 @default.
• W2043012583 hasRelatedWork W2093676869 @default.
• W2043012583 hasRelatedWork W2118560029 @default.
• W2043012583 hasRelatedWork W2360961226 @default.
• W2043012583 hasRelatedWork W3157990394 @default.

• next